Targeting of mirna precursors
OwnerAngus Iain Lamond, Motoharu Ono +1inventors
InventorsAngus Iain Lamond, Motoharu Ono, Kayo Ono
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Abstract
The present invention relates to a method of targeting mi RNA and/or premiRNA molecules in order to treat diseases that are linked with mi RNA expression, such as certain cancers. The present invention also provides modified sno RNA molecules for targeting mi RNA molecules for use in treating diseases that are linked with mi RNA expression, such as certain cancers.
Claims17
A modified snoRNA molecule comprising a nucleic acid sequence substantially complementary to a portion of a pre-miRNA and/or miRNA molecule associated with disease.
A method for inducing apoptosis, comprising reducing or inhibiting a miR precursor in a cancer cell or other cell displaying abnormal cell proliferation.
Dependencies are inferred from the claim text.