Methods for Modulating Bacterial Virulence and Related Compounds
AssigneeBoard of Regents, The University of Texas System
InventorsVanessa Sperandio, John R. Falck
Life of this patent
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Abstract
The present invention relates to compounds and methods for the treatment of bacterial infections. The compounds and methods involve the disruption of the QseC signaling pathway which modulates the virulence of some bacteria. This methodology for treatment of bacterial infections reduces evolutionary pressure to develop resistance because the bacteria are not killed in the process.
Claims38
A method of treating or preventing bacterial infection in a subject, comprising administering to the subject an effective amount of the following molecular formula:
- wherein:
- R1 and R2 are each independently hydrogen, cyano, nitro, halo, —C(O)OCH2CH3, C1-C8-alkyl, C1-C8-aryl, or a substituted version of those groups;
- R3 is hydrogen or C1-C6-alkyl;
- or
- R4 is C1-C10-aryl, C1-C6-alkyl, C6-C12-cycloalkyl, or a substituted version of those groups or a pharmaceutically acceptable salt, thereof.
29-31. (canceled)
A method of treating or preventing bacterial infection in a subject, comprising administering to the subject an effective amount of the following molecular formula:
- or a pharmaceutically acceptable salt, thereof.
(canceled)
37-56. (canceled)
A compound selected from the group consisting of CF325, CF326, CF327, CF329, CF330, CF331, CF332, CF333, CF334, CF338, CF339, CF340, CF341, CF342, CF343, CF344, CF345, CF349, CF350, CF351, CF352 and CF354.
(canceled)
A compound of the formula:
- wherein:
- X1 is
- wherein:
- R6 is hydrogen or C1-C3-alkyl;
- R7 and R8 are each independently hydrogen, cyano, nitro, halo, —C(O)OCH2CH3,
- and
- Y1 is methyl,
- wherein:
- X2, X3, and X4 are each independently hydrogen, halo, or —OMe.
Dependencies are inferred from the claim text.