TREATMENT OF OVARIAN CANCER WITH 2-AMINO-4H-NAPHTHO[1,2-b]PYRAN-3-CARBONITRILES
AssigneeMemorial Sloan Kettering Cancer Center
InventorsMalcolm Moore, Server A. Ertem
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Abstract
Methods for inhibiting the growth of ovarian cancer cells or other serosal cancer cells are disclosed. The method involves exposing the cells to a 2-amino-4H-naphtho[1,2-b]pyran-3-carbonitrile of formula: whereinY is CR1 or N and Z is CR5 or N.
Claims20
A method of treating serosal cancer comprising administering to a patient diagnosed with serosal cancer a compound of formula:
- wherein:
- Y is CR3 or N;
- Z is CR5 or N;
- R1 is chosen from H and (C1-C8)hydrocarbon;
- R2 is chosen from H, halogen, —CF3, —NO2, —CN, —NHC(═O)(C1-C8)hydrocarbon and —NHS2(C1-C8)hydrocarbon;
- R3 is chosen from H and halogen;
- R4 is chosen from H, halogen, —NO2, —CN, (C1-C8)hydrocarbon and —O—(C1-C8)hydrocarbon;
- and R5 is chosen from H, halogen, —NO2, —CN, —CH3, —NHC(═O )(C1-C8)hydrocarbon and —NHSO2(C1-C8)hydrocarbon.
(canceled)
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of formula:
(canceled)
A method for inhibiting the growth of an ovarian cancer cell or other cancer cell with a pericellular coat comprising exposing said cell to a compound of formula:
- wherein:
- Y is CR'or N;
- Z is CR5 or N;
- R1 is chosen from H and (C1-C8)hydrocarbon;
- R2 is chosen from H, halogen, —CF3, —NO2, —CN, —NHC(═O)(C1-C8)hydrocarbon and —NHSO2(C1-C8)hydrocarbon;
- R3 is chosen from H and halogen;
- R4 is chosen from H, halogen, —NO2, —CN, (C1-C8)hydrocarbon and —O—(C1-C8)hydrocarbon;
- and
- R5 is chosen from H, halogen, —NO2, —CN, —NHC(═O)(C1-C8)hydrocarbon and —NHSO2(C1-C8)hydrocarbon.
Dependencies are inferred from the claim text.