Benzo-fused heterocyclic derivatives useful as agonists of gpr120
AssigneeJanssen Pharmaceutica NV
InventorsZhihua Sui, Nalin Subasinghe
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Abstract
The present invention is directed to benzo-fused heterocyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GPR120. More particularly, the compounds of the present invention are agonists of GPR120, useful in the treatment of, such as for example, Type II diabetes mellitus.
Claims29
A compound of formula (I)
- wherein
- is selected from the group consisting of,
- R1 is selected from the group consisting of cyano, C1-6alkyl, -(hydroxy substituted C1-4alkyl), chloro substituted C1-4alkyl, fluoro substituted C1-4alkyl, C2-4alkenyl, chloro substituted C2-4alkenyl, fluoro substituted C2-4alkenyl, C2-4alkynyl, —(C1-4alkyl)-O—(C1-4alkyl), —(C1-4alkyl)-SO—(C1-4alkyl), —(C1-4alkyl)-SO2—(C1-4alkyl), —(C1-4alkyl)-NRARB, —(C1-4alkyl)-NRA—C(O)—(C1-4alkyl), —(C1-4alkyl)-NRA—SO2—(C1-4alkyl), —C(O)OH, —C(O)O—(C1-4alkyl), —C(O)—(C1-4alkyl), —C(O)—NRARB, C3-8cycloalkyl, —(C1-4alkyl)-(C3-8cycloalkyl), aryl and —(C1-2alkyl)-(aryl);
- wherein RA and RB are each independently selected from the group consisting of hydrogen and C1-4alkyl;
- R2 is selected from the group consisting of hydrogen, halogen and C1-4alkyl;
- R3 is selected from the group consisting of hydrogen, chloro and fluoro;
- R4 and R5 are each independently selected from the group consisting of hydrogen, halogen, cyano, C1-4alkyl, chloro substituted C1-4alkyl, fluoro substituted C1-4alkyl, C2-4alkenyl, chloro substituted C2-4alkenyl, fluoro substituted C2-4alkenyl, C2-4alkynyl, chloro substituted C2-4alkynyl, fluoro substituted C2-4alkynyl, C1-4alkoxy, fluoro substituted C1-4alkoxy, —O—(C1-4alkyl)-O—(C1-4alkyl), —(C1-4alkyl)-O—(C1-4alkyl), —(C1-4alkyl)-SO2—(C1-4alkyl), —(C2-4alkenyl)-SO2—(C1-4alkyl), —C(O)—NRCRD, —O-(aryl) and —O—(C1-2alkyl)-aryl;
- wherein RC and RD are each independently selected from the group consisting of hydrogen and C1-4alkyl;
- provided that at least one of R4 or R5 is selected from the group consisting of hydrogen, chloro and fluoro;
- alternatively, wherein
- R4 and R5 may be taken together with the carbon atoms to which they are bound to form a ring structure selected from the group consisting of
- W is selected from the group consisting of C(R9);
- wherein R9 is selected from the group consisting of hydrogen, fluoro and bromo;
- alternatively, wherein
- W may be N;
- R6 and R7 are each independently selected from the group consisting of hydrogen, halogen, cyano, C1-6alkyl, chloro substituted C1-4alkyl, fluoro substituted C1-4alkyl, bromo substituted C1-4alkyl, C1-4alkoxy and fluoro substituted C1-4alkoxy;
- alternatively, wherein
- and W is C(R9), R6 and R7 may be taken together with the carbon atoms to which they are bound to form
- R8 is selected from the group consisting of hydrogen, halogen, cyano, C1-6alkyl, chloro substituted C1-4alkyl, fluoro substituted C1-4alkyl, bromo substituted C1-4alkyl, C1-4alkoxy, fluoro substituted C1-4alkoxy and —(C1-4alkyl)-C(O)OH;
- R0 is selected from the group consisting of —CH2OH and —C(O)OH;
- or a pharmaceutically acceptable salt thereof.
A compound a herein described.
A product prepared according to any of the processes described herein.
A method of treating any disorder herein described comprising administering to a subject in need thereof a therapeutically effective amount of a compound as herein described.
Dependencies are inferred from the claim text.