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US 2014/0275167 A1Published application
Hepatitis b antiviral agents
AssigneeNovira Therapeutics, Inc.
InventorGeorge D. Hartman
Life of this patent
Estimating the term…
Abstract
Provided herein are compounds useful for the treatment of HBV infection in man.
Claims23
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- Ring A is selected from:
- wherein:
- G is N, and Q is CH2 or NR3, or
- G is NR3, and Q is CH or N, or
- G is CH, and Q is NR3, or
- G is CH2, and Q is N;
- and
- represents a single or double bond;
- T is selected from —C(O)—, —NH(C(O))—, and —S(O)2—;
- V is selected from —C(O)— and —S(O)2—;
- R1 in each occurrence is independently selected from halo, —CN, C1-6alkyl, —OC1-6alkyl, and —NO2, wherein the C1-6alkyl is optionally substituted with one to three halo;
- R2 in each occurrence is independently selected from hydrogen, halo, and C1-6alkyl;
- R3 is selected from H and C1-6alkyl;
- R4 in each occurrence is independently selected from halo, C1-6alkyl, monocyclic 5 to 7-membered carbocyclyl, monocyclic 5 to 7-membered heterocyclyl, —OR4a, —SR4a, and —N(R4a)2 wherein the C1-6alkyl, monocyclic 5 to 7-membered carbocyclyl, and monocyclic 5 to 7-membered heterocyclyl are optionally substituted with one or more R40;
- R4a in each occurrence is independently selected from H, C1-6alkyl, monocyclic 5 to 7-membered carbocyclyl, and monocyclic 5 to 7-membered heterocyclyl, wherein said C1-6alkyl, monocyclic 5 to 7-membered carbocyclyl, and monocyclic 5 to 7-membered heterocyclyl, are optionally and independently substituted with one or more R40;
- R5 is selected from H and C1-6alkyl;
- R40 in each occurrence is independently selected from halo, —CN, C1-6alkyl, monocyclic 5 to 7-membered carbocyclyl, monocyclic 5 to 7-membered heterocyclyl, —OR40a, —SR40a, —N(R40a)2, —NO2, —C(O)R40b, and —C(O)2R40a;
- R40a in each occurrence is independently selected from H, C1-6alkyl, monocyclic 5 to 7-membered carbocyclyl, and monocyclic 5 to 7-membered heterocyclyl;
- R40b in each occurrence is independently selected from C1-6alkyl, monocyclic 5 to 7-membered carbocyclyl, and monocyclic 5 to 7-membered heterocyclyl;
- w is 0, 1, 2, or 3;
- x is 0 or 1;
- and
- y is 0, 1, or 2.
22 more elements
A compound of Formula IX:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- Ring A is selected from:
- wherein:
- G is N, and Q is CH2 or NR3, or
- G is NR3, and Q is CH or N, or
- G is CH, and Q is NR3, or
- G is CH2, and Q is N;
- and
- represents a single or double bond;
- T is selected from —C(O)—, —NH(C(O))—, and —S(O)2—;
- V is selected from —C(O)— and —S(O)2—;
- R1 in each occurrence is independently selected from halo, —CN, C1-6alkyl, —OC1-6alkyl, and —NO2, wherein the C1-6alkyl is optionally substituted with one to three halo;
- R2 in each occurrence is independently selected from hydrogen, halo, and C1-6alkyl;
- R3 is selected from H and C1-6alkyl;
- R6 is H or C1-6 alkyl;
- R7 is H or C1-6 alkyl;
- n is 1, 2, 3, 4, 5, or 6;
- and
- w is 0, 1, 2, or 3.
17 more elements
A compound of Formula XI:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- Ring A is selected from:
- wherein:
- G is N, and Q is CH2 or NR3, or
- G is NR3, and Q is CH or N, or
- G is CH, and Q is NR3, or
- G is CH2, and Q is N;
- and
- represents a single or double bond;
- T is selected from —C(O)—, —NH(C(O))—, and —S(O)2—;
- V is selected from —C(O)— and —S(O)2—;
- R1 in each occurrence is independently selected from halo, —CN, C1-6alkyl, —OC1-6alkyl, and —NO2, wherein the C1-6alkyl is optionally substituted with one to three halo;
- R2 in each occurrence is independently selected from hydrogen, halo, and C1-6alkyl;
- R3 is selected from H and C1-6alkyl;
- R6 is H or C1-6 alkyl;
- R7 is H or C1-6 alkyl, and R8 is a bond or C1-C3 alkylene, wherein the C1-C3 alkylene is optionally substituted with 1-3 substituents selected from R10, or —R8—OR7 is absent;
- R9 in each occurrence is independently OH, halo, C1-C6 alkyl, C1-C6 alkyl-OH, C1-C6 fluoroalkyl, C1-C6 heteroalkyl, C3-C10 cycloalkyl, a C3-C10 heterocycloalkyl, aryl, heteroaryl, —C1-C4 alkyl-(C3-C10 cycloalkyl), —C1-C4 alkyl-(C3-C10 heterocycloalkyl), —C1-C4 alkyl-(aryl), or —C1-C4 alkyl-(heteroaryl), and wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring is optionally substituted with 1-5 substituents selected from R10;
- R10 is independently selected at each occurrence from the group consisting of halo, —CN, —NO2, —C1-C6 alkyl, —C1-C6 alkoxy, —C1-C6 fluoroalkyl, —C1-C6 heteroalkyl, and C(O)—C1-C6 alkyl;
- w is 0, 1, 2, or 3;
- m is 0, 1, 2, or 3;
- and
- z is 0, 1, 2, or 3.
20 more elements
(canceled)
19-33. (canceled)
Dependencies are inferred from the claim text.