Spintraps and spin labels and their hydroxylamines for peri- and post-menopausal syndrome

A method for the treatment of perimenopausal and post-menopausal symptoms in persons in need thereof with a spin-label or its reduced forms at a pharmacologically-effective dose.

A method for the treatment of perimenopausal and post-menopausal symptoms in persons in need thereof where the spin label is TEMPO (2,2,6,6-tetramethyl-1-piperidinyl-1-oxyl) or a pharmacologically-active derivative. These include 4-hydroxy-TEMPO (TEMPOL), 4 amino-TEMPO, Mito-TEMPOL and/or reduced derivatives such as TEMPO-H or TEMPOL-H, as well as their pharmacologically-active esters, ethers or amides.

A method for the treatment of perimenopausal and post-menopausal symptoms in persons in need thereof where the spin-trap is phenylbutylnitrone or 2-methyl, 2-nitrosopropane or their reduced forms.

A method for the treatment of perimenopausal and post-menopausal symptoms in persons in need thereof where the pharmacologically-effective dose is 0.01-2000 mg per day of a pharmacologically-active nitroxide, nitrone, or nitroso spin-trap, spin label or their equivalent hydroxylamine or other reduced derivatives administered by suitable means such as orally, sublingually, transrectally, dermally, intramuscularly, or intravenously.

A method for the treatment of perimenopausal and post-menopausal symptoms in persons in need thereof where the spin trap or spin label is administered along with a reducing agent.