COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY
AssigneeThe Trustees of Columbia University in the City of New York
InventorsDonald W. Landry, Tae-Wan Kim, Shi-Xian Deng, Gangli Gong, Jeremy C. Hwang, Yuli Xie, Yidong Liu, Kirsten Alison Rinderspacher
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds with activity as BACE1 and NFκB modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
Claims18
A composition comprising a compound of Formula I:
- wherein R1, R2, R3, R4, and R5 are independently selected for each occurrence from the group consisting of hydrogen, halogen, alkyl, aryl, alkoxy, aryloxy, alkylthiol, arylthiol, CN, and NO2;
- and
- wherein R10 is selected from the group consisting of substituted or unsubstituted alkyl, cycloalkyl, aryl, heteroaryl and alkenyl.
4-9. (canceled)
Dependencies are inferred from the claim text.