Desethylhydroxychloroquine for the treatment of diseases associated with inflammation
AssigneesThe Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the Department of Veterans Affairs
InventorsWilliam H. Robinson, Jeremy Sokolove, Qian Wang
Life of this patent
Estimating the term…
Abstract
Compositions and methods are provided for inhibiting or treating the early and established stages of inflammatory diseases by administration of an effective dose of the desethylhydroxychloroquine (DHCQ). A benefit of the methods is the ability to deliver a dose of agent that is effective in treating inflammation while sparing the individual from retinal toxicity.
Claims34
A pharmaceutical composition comprising:
- a dose of an aminoquinoline or salt and/or ester thereof effective in treating inflammation with decreased retinal toxicity;
- and a pharmaceutically acceptable excipient.
4-5. (canceled)
(canceled)
14-18. (canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method of treating an inflammatory disease comprising:
- administering to an individual in need thereof a dose of an aminoquinoline or salt and/or ester thereof effective in treating inflammation substantially without retinal toxicity;
- and an effective dose of a statin or a salt and/or ester thereof.
(canceled)
(canceled)
Dependencies are inferred from the claim text.