Dye free liquid therapeutic solution
OwnerMahesh Sudhakar BHARATI, Houphouet Hyacinthe YARABEinventors
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Abstract
A liquid composition is provided. The composition includes at least one active pharmaceutical ingredient dissolved in a liquid carrier system. The liquid carrier includes polyethylene glycol and a co-solvent selected from the group consisting of: propylene glycol, glycerin, and a sugar alcohol. The composition is essentially dye tree, present as a single-phase at room temperature, and optionally contains water.
Claims23
A liquid composition comprising an active pharmaceutical ingredient dissolved in a liquid carrier system, wherein the liquid carrier comprises polyethylene glycol and a co-solvent selected from the group consisting of:
- propylene glycol, glycerin, and a sugar alcohol, wherein the composition is essentially dye free, is present as a single-phase at room temperature, and optionally further comprises water.
The liquid composition of wherein the composition comprises:
- (i) 15-50% by weight of polyethylene glycol having molecular weight of 1300-1600;
- (ii) 2-25% by weight of propylene glycol;
- (iii) 2-13% by weight of glycerin;
- (iv) 2%-20% by weight of sorbitol solution;
- and
- (v) 0-50% by weight of water.
16-28. (canceled)
(canceled)
32-33. (canceled)
A method of preparing a liquid formulation containing an active pharmaceutical ingredient, comprising the steps of:
- (a) solublizing sweetening agents in an aqueous vehicle
- (b) solublizing of preservative In propylene glycol
- (c) adding of co-solvents comprising glycerin, sorbitol, and PEG, in aqueous vehicle
- (d) adding and dissolving active pharmaceutical ingredient,
- (e) adjusting the volume to a standard volume by adding additional sweeteners, co-solvents, flavoring system, and/or water.
Dependencies are inferred from the claim text.