Compositions of a polyorthoester and an aprotic solvent
AssigneeHeron Therapeutics, Inc.
InventorsThomas B. Ottoboni, Lee Ann Lynn Schillinger
Life of this patent
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Abstract
Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an aprotic solvent, and a drug are described. The solvent is selected to modulate release of drug from the composition, where, in some embodiments, the solvent is rapidly released after administration and provides a corresponding rapid rate of drug release. Alternatively, in other embodiments, the solvent is slowly released from the composition after its administration, and provides a correspondingly slow rate of drug release.
Claims21
A delivery system, comprising:
- a polyorthoester;
- an aprotic solvent in which the polyorthoester is miscible to form a single phase;
- and
- a local amide- or anilide-type anesthetic dispersed or solubilized in the single phase;
- wherein the anesthetic is released from the system over a period of between approximately 1 day and approximately 8 weeks.
A method of administering a local amide- or anilide-type anesthetic, comprising dispensing from a needle a delivery system comprising:
- a polyorthoester, an aprotic solvent in which the polyorthoester is miscible to form a single phase, and a local amide- or anilide-type anesthetic dispersed or solubilized in the single phase, wherein the anesthetic is released from the system over a period of between approximately 1 day and approximately 8 weeks.
A method of providing local anesthesia to a patient, comprising administering to a patient a delivery system comprising a polyorthoester, an aprotic solvent in which the polyorthoester is miscible to form a single phase, and a local amide- or anilide-type anesthetic dispersed or solubilized in the single phase, wherein the anesthetic is released from the system over a period of between approximately 1 day and approximately 8 weeks, in an amount effective for reducing or preventing pain.
Dependencies are inferred from the claim text.