Combinations of Opioid/TLR4 Antagonist and a Cyclooxygenase (COX) Inhibitor for Use in the Treatment of Pain
AssigneeAllodynic Therapeutics, LLC
InventorAnnette Channa Toledano
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Abstract
Disclosed are compositions for treatment of pain comprising a first compound and a second compound, the first compound is an opioid antagonist that treats pain by blocking Toll-like receptor 4 (TLR4) and the second compound is a cyclooxygenase (COX) inhibitor that enhances the pain treatment effect of the first compound. Examples of opioid antagonist include naltrexone and naloxone. Examples of cyclooxygenase inhibitors include ibuprofen, naproxen, meloxicam, diclofenac and meclofenamic acid, synergistic pharmaceutical compositions thereof, and their use in the treatment, prevention, and reversal of neuropathic pain and nociceptive pain with an allodynic component.
Claims17
A composition for treatment of pain in a mammal comprising a synergistic ratio of an opioid/TLR4 antagonist, or pharmaceutically acceptable salts or solvates thereof and a cyclooxygenase (COX) inhibitor, or pharmaceutically acceptable salts or solvates thereof.
A composition according to claim 9, wherein naltrexone and ibuprofen, or pharmaceutically acceptable salts or solvates of any thereof, are in a weight to weight combination range which corresponds to a synergistic combination of 1:90 parts by weight.
Dependencies are inferred from the claim text.