Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors
AssigneeThe Johns Hopkins University
InventorsJohn P. Toscano, Daryl A. Guthrie
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Abstract
The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.
Claims24
A compound of formula (I) or (II)
- or a pharmaceutically acceptable salt or hydrate thereof, wherein:
- X and Z are independently selected from —O—, —NR—, —S—, —CR3—, and —CR3R4—;
- Y is selected from —C(═O)—, —C(═S)—, —C(═NR5)—, and —CR5R6—;
- R is selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 alkoxy, C5-C10 aryl, —C(═O)R7, —C(═S)R7, —C(═NR7)R8, and —C(═NOR7)R8, wherein the alkyl, alkenyl, alkynyl, alkoxy and aryl are unsubstituted or substituted with one or more substituents;
- R1 is selected from —H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C5-C10 aryl, C5-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, and C5-C10 heteroaryl, wherein the alkyl, alkenyl, alkynyl, aryl, heterocycloalkyl, heterocycloalkenyl and heteroaryl are unsubstituted or substituted with one or more substituents;
- and
- R2, R3, R4, R5, R6, R7 and R8 are independently selected from —H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C5-C10 aryl, C5-C10 heterocycloalkyl, C5-C10 heterocycloalkenyl, C5-C10 heteroaryl, wherein the alkyl, alkenyl, alkynyl, aryl, heterocycloalkyl, heterocycloalkenyl and heteroaryl are unsubstituted or substituted with one or more substituents.
Dependencies are inferred from the claim text.