Crystalline form of 6-[(4s)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AssigneeBristol-Myers Squibb Company
InventorsJun Qiu, Qui Gao, Shuang Liu, Min Hu, Yuh-Lin Allen Yang, Matthew Isherwood, Rasidul Amin
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Abstract
The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.
Claims15
Form N-1 of
Form N-1 of
- characterized by the following unit cell parameters:
- Cell dimensions:
- a=8.4299(4) Å
- b=6.0698(3) Å
- c=19.0689(12) Å
- alpha=90°
- beta=100.169(2)°
- gamma=90°
- Space group Monoclinic, P21
- Volume 960.39(9) Å3
- Z, Calculated density 2, 1.267 g/cm3
- wherein measurement of said crystalline form is at a temperature between about 20° C. to about 25° C.
Form N-1 of
- characterized by fractional atomic coordinates within the unit cell as listed in Table 3.
Form N-1 of
- with characteristic peaks in the powder X-ray diffraction pattern at values of two theta of 4.6±0.1, 9.4±0.1, 10.6±0.1, 14.1±0.1, 15.4±0.1, 18.2±0.1, 19.5±0.1 at a temperature between about 20° C. and about 25° C.
Form N-1 of
- characterized by a melt with decomposition endotherm with onset typically in the range of 235-245° C.
Substantially pure Form N-1 of
A pharmaceutical composition comprising Form N-1 of
- and a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising Form N-1 of
- in combination with one or more additional drugs.
A method of treating depression in a mammal comprising administering to the mammal a therapeutically-effective amount of Form N-1 of
A method of treating anxiety disorders in a mammal comprising administering to the mammal a therapeutically-effective amount of Form N-1 of
A method of treating pain in a mammal comprising administering to the mammal a therapeutically-effective amount of Form N-1 of
A method of treating obesity in a mammal comprising administering to the mammal a therapeutically-effective amount of Form N-1 of
Dependencies are inferred from the claim text.