Pyrrole amide inhibitors

A compound of formula (I) or a pharmaceutically acceptable salt thereof

• wherein
• R1 is C1-C3 alkyl;
• R2 is hydrogen or C1-C3 alkyl;
• R3 is —C(O)—C1-C3 alkyl, COOH, or —C(O)NR8R9;
• R8 and R9 are chosen from one of the following groups:
• (i) R8 and R9 are both H;
• (ii) R8 is H and R9 is C1-C3 alkylene-C(O)O—C1-C3 alkyl or OH;
• and
• (iii) R8 is C1-C3 alkylene-aryl and R9 is C1-C3 alkylene-C(O)—C1-C3 alkyl;
• R10 is aryl or heteroaryl, wherein R10 may be substituted with 1 to 3 substituents designated as R40, R41, and R42 and independently selected from the group consisting of:
• NO2, NR20R22, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—C1-C6 alkyl, —O—C1-C6 haloalkyl, C1-C3 alkylene-OH, C1-C3 alkylene-C(O)OH, C1-C3 alkylene-C(O)O—C1-C4 alkyl, C2-C3alkenylene-O—C1-C3alkyl, —NHC(O)—C1-C3 alkyl, —NH—SO2—C1-C3 alkyl, —NH—SO2—C1-C3 haloalkyl, —SO2—NH2, —C(O)—NR20R22, and -L-R12,
• wherein L is absent or is —C1-C3alkylene-, —C2-C3alkenylene-, —NH—, —NH—C1-C3alkylene-, —NR26—, —NHS(O)2—, NHS(O)2—C1-C3alkylene-, —NH—C(O)—C1-C3alkylene-, —C(O)—, —C(O)—NH—C1-C3alkylene-, and —O—;
• R12 is selected from the group consisting of:
• C1-C6 alkyl, C1-C6 haloalkyl, C3-C10 cycloalkyl, 3 to 8 membered heterocycloalkyl, 5 to 12 membered heteroaryl, and aryl, which may be substituted with one, two, or three substituents designated R15, R16, and R17,
• R15, R16, and R17 are independently selected from the group consisting of:
• OH, CN, halo, C1-C3 alkyl, C1-C3 haloalkyl, —O—C1-C3 alkyl, —O—C1-C3 haloalkyl, —C1-C3 alkylene-OH, —C1-C3 alkylene-C(O)O—C1-C3 alkyl, —C(O)—C1-C4 alkyl, —C(O)OC1-C4 alkyl, —C(O)NH—C1-C3 alkylene-NR30R32, —C(O)NR30R32, —O—C1-C4 alkyl-NR30N32, —NR30R32, —NHC(O)O—C1-C4 alkyl, —NH—S(O)2—C1-C3 alkyl, —NH—S(O)2—C1-C3 haloalkyl, —S(O)2—C1-C3 alkyl, aryl, —O-aryl, —C1-C3 alkylene-aryl, C3-C6 cycloalkyl, heterocycloalkyl, —C1-C3 alkylene-heterocycloalkyl, —C(O)-heterocycloalkyl, 5 to 12 membered heteroaryl, and —C(O)NH—C1-C3alkylene-heteroaryl,
• wherein said heterocycloalkyl, heteroaryl or aryl groups on R15, R16, and R17 may be independently substituted with 1 to 3 substituents selected from the group consisting of:
• C1-C3-alkyl, C1-C3-haloalkyl, —O—C1-C3-alkyl, —O—C1-C3-haloalkyl, halo, —NH—S(O)2—C1-C3 alkyl, —NH—S(O)2—C1-C3 haloalkyl, and —S(O)2—C1-C3 alkyl,
• R26 is C1-C3 alkylene-C3-C6 cycloalkyl;
• R20 and R22 are independently selected from the group consisting of H and C1-C6 alkyl;
• and
• R30 and R32 are independently selected from the group consisting of H and C1-C4alkyl.