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US 2014/0275078 A1Published application
Compositions and methods for treating cancer using pi3kb inhibitor and mapk pathway inhibitor, including mek and raf inhibitors
AssigneeSanofi
InventorsCarlos Garcia-Echeverria, Loïc Vincent, Angela Virone-Oddos
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Abstract
The present invention relates to compositions comprising at least one MAPK pathway inhibitor including MEK and RAF inhibitors and at least one PI3Kβ inhibitor, and also to uses thereof for the treatment of cancer.
Claims27
A pharmaceutical combination comprising:
- a compound of formula (I):
- or a pharmaceutically acceptable salt thereof,
- and
- at least one MAPK pathway inhibitor, or a pharmaceutically acceptable salt thereof.
1 more element
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A method of treating a patient with cancer comprising administering to the patient simultaneously, separately or sequentially:
- a therapeutically effective amount of compound of formula (I):
- or a pharmaceutically acceptable salt thereof,
- and
- a therapeutically effective amount of at least one MAPK pathway inhibitor, or a pharmaceutically acceptable salt thereof.
1 more element
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A kit comprising:
- at least one compound of formula (I):
- or a pharmaceutically acceptable salt thereof,
- at least one MAPK pathway inhibitor chosen from the group consisting of:
- the compound (2a):
- or a pharmaceutically acceptable salt thereof,
- and
- the compound (2b):
- or a pharmaceutically acceptable salt thereof,
- and optionally, instructions for use.
6 more elements
Dependencies are inferred from the claim text.