Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative

A compound of formula 1:

• or pharmaceutically acceptable salt thereof,
• R1 is optionally substituted heteroaryl, or optionally substituted heteroalicyclic;
• R2 is hydrogen, optionally substituted alkyl, optionally substituted alkylcarbonyl, optionally substituted alkoxycarbonyl, or optionally substituted aminocarbonyl;
• R3 and R4 are each independently hydrogen, halogen, cyano, nitro, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted aminocarbonyl, or the following group:
• wherein
• X is optionally substituted five membered heteroaryl or optionally substituted heteroalicyclic,
• R8a is optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heteroalicyclic,
• R8b and R8c are each independently hydrogen, alkyl, halogen, cyano, amino, nitro, hydroxy, trifluoromethyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heteroalicyclic, and
• n is the integral 0 to 2,
• R5 is hydrogen, halogen, cyano, nitro, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted aminocarbonyl, or the following group:
• wherein
• Y is optionally substituted five membered heteroaryl provided that the five membered heteroaryl is not the following group:
• wherein R9a is same as the above definition,
• R9a is optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heteroalicyclic,
• R9b and R9c are each dependently hydrogen, alkyl, halogen, cyano, amino, nitro, hydroxy, trifluoromethyl, and
• m is the integral 0 to 2, and
• at least one of R3, R4 and R5 is the following group:
• X, R8a, R8b, R8c and n are same as the above definition, or the following group:
• Y, R9a, R9b, R9c and m are same as the above definition;
• R6 is hydrogen, halogen, cyano, nitro, hydroxy, amino, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted alkoxycarbonyl, optionally substituted alkyl carbonyl, or optionally substituted aminocarbonyl;
• and
• R7 is hydrogen, optionally substituted alkyl, or optionally substituted cycloalkyl.