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US 2014/0275070 A1Published application
Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
AssigneeThe Regents of the University of Michigan
InventorsJolanta Grembecka, Tomasz Cierpicki, Dmitry Borkin, Jay L. Hess, Duxin Sun, Xiaoqin Li
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Abstract
The present invention relates generally to thienopyrimidine and thienopyridine class compounds and methods of use thereof. In particular embodiments, the present invention provides compositions comprising thienopyrimidine class compounds and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins (e.g., for the treatment of leukemia, solid cancers and other diseases dependent on activity of MLL1 and MLL2 or menin).
Claims6
A composition comprising a compound having the structure of one of:
Dependencies are inferred from the claim text.