US 2014/0275065 A1 · SUBSTITUTED 7-AZABICYLES AND THEIR USE AS OREXIN RECEPTOR MODULATORS

Abstract

The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphthalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, thiazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimidazolyl, or indazolyl; R1 is H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl, or dialkylamino; R2 is H, alkyl, alkoxy, hydroxyalkylene, or halo; Z is NH, N-alkyl, or O; R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinazolinyl, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with a one or two substituents independently selected from the group consisting of alkyl, alkoxy, or halo; and n is 0 or 1. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.

Claims91

Dependent claims

A compound of formula I:

or an enantiomer or diastereomer thereof;
or a pharmaceutically acceptable salt thereof;
wherein
ring A is phenyl, naphthalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyl, thiazolyl, isoxazolyl, pyrazolyl, imidazothiazolyl, benzimidazolyl, or indazolyl;
R1 is H, alkyl, alkoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, piperazinyl, pyrazolyl, oxadiazolyl, pyrrolidinyl, thiophenyl, morpholinyl, or dialkylamino;
R2 is H, alkyl, alkoxy, hydroxyalkylene, or halo;
Z is NH, N-alkyl, or O;
R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinazolinyl, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, or triazolopyrazinyl, optionally substituted with a one or two substituents independently selected from the group consisting of alkyl, alkoxy, or halo;
and
n is 0 or 1.

7 more elements

A compound selected from the group consisting of

Ex.
Compound
No.
Compound
Name
1
(5-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
2
(±)-(6-methyl-3- (pyrimidin-2-yl)pyridin-2- yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
3A
(6-methyl-3-(pyrimidin-2- yl)pyridin-2- yl)((1S*,2R*,4R*)-2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
3B
(6-methyl-3-(pyrimidin-2- yl)pyridin-2- yl)((1R*,2S*,4S*)-2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
4
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
5A
(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)((1S,2R,4R)-2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
5B
(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)((1R,2S,4S)-2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
6
(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)((1S,2R,4R)-2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
7
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
8A
((1S,2R,4R)-2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
8B
((1R,2S,4S)-2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
9
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
10A
((1S,2R,4R)-2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
10B
((1R,2S,4S)-2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
11
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2-(thiophen-2- yl)phenyl)methanone
12A
((1S*,2R*,4R*)-2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2-(thiophen-2- yl)phenyl)methanone
12B
((1R*,2S*,4S*)-2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2-(thiophen-2- yl)phenyl)methanone
13
(±)-(5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((4- (trifluoromethyl)pyrimidin- 2-yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
14
(±)-(5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((5- (trifluoromethyl)pyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
15
(±)-(5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((3- (trifluoromethyl)pyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
16
(±)-(5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((6- (trifluoromethyl)pyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
17
(±)-(5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((4- methylpyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
18
(±)-(5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((6- methylpyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
19
(±)-(5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((5- methylpyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
20
(±)-(2-(((3,6- dimethylpyrazin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
21
(±)-(5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((3- (trifluoromethyl)quinoxalin- 2-yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
22
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
23
(±)-2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(quinolin-8- yl)methanone
24
(±)-2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(naphthalen-1- yl)methanone
25
(±)-2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2-methylnaphthalen-1- yl)methanone
26
(±)-2-(1H-pyrazol-1- yl)phenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
27
(±)-2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(3-phenylfuran-2- yl)methanone
28
(±)-(2-ethoxynaphthalen-1- yl)(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
29
(±)-(5-(2-fluorophenyl)-2- methylthiazol-4-yl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
30
(±)-(5-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
31
(±)-(2-fluoro-6-(pyrimidin- 2-yl)phenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
32
(±)-(5-fluoro-2-(pyrimidin- 2-yl)phenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
33
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methyl-2-(pyrimidin- 2-yl)phenyl)methanone
34
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((quinoxalin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
35
(±)-(2-fluoro-6-(2H-1,2,3- triazol-2-yl)phenyl)(2- ((quinoxalin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
36
(±)-(5-methyl-2-(2H-1,2,3- triazol-2-yl)phenyl)(2- ((quinoxalin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
37
(±)-(5-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl)(2- ((quinoxalin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
38
(±)-(5-methyl-2- (pyrimidin-2-yl)phenyl)(2- ((quinoxalin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
39
(±)-(2-(((4,6- dimethylpyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
40
(±)-2-(((4,6- dimethylpyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(3-methyl-5- phenylisoxazol-4- yl)methanone
41
(±)-(2-(((4,6- dimethylpyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2-ethoxynaphthalen-1- yl)methanone
42
(±)-(2-(((4,6- dimethylpyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2- ethoxyphenyl)methanone)
43
(±)-(2-(((4,6- dimethylpyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2-fluoro-6-(pyrimidin- 2-yl)phenyl)methanone
44
(±)-(2-(((4,6- dimethylpyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-fluoro-2-(pyrimidin- 2-yl)phenyl)methanone
45
(±)-(2-(((4,6- dimethylpyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methyl-2-(pyrimidin- 2-yl)phenyl)methanone
46
(±)-(2-(((4,6- dimethylpyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2-(thiophen-2- yl)phenyl)methanone
47
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-(((5- (trifluoromethyl)pyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
48
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2-(((5- (trifluoromethyl)pyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
49
(±)-(2-(((5-bromopyridin- 2-yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
50
(±)-(2-(((5-bromopyridin- 2-yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2- methoxyphenyl)methanone
51
(±)-(2-(((5-bromopyridin- 2-yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(3-ethoxy-6- methylpyridin-2- yl)methanone
52
(±)-(3-fluoro-2-(pyrimidin- 2-yl)phenyl)2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
53
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((pyridazin-3- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
54
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-(((2-methylpyridin-3- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
55
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-(((3-methylpyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
56
(±)-(2-(((1-methyl-1H- pyrazol-5-yl)oxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)(6-methyl-3-(2H- 1,2,3-triazol-2-yl)pyridin- 2-yl)methanone
57
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((pyridin-4- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
58
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((pyridin-3- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
59
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((pyrimidin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
60
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((pyrazin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
61
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2- ((pyrimidin-4- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
62
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-(((6-methylpyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
63
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(oxazol-2- yl)pyridin-2-yl)methanone
64
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(pyrimidin- 2-yl)pyridin-2- yl)methanone
65
(±)-(3,6′-dimethyl-[2,3′- bipyridin]-2′-yl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
66
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(3-methyl- 1,2,4-oxadiazol-5- yl)pyridin-2-yl)methanone
67
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(3-methyl- 1H-pyrazol-1-yl)pyridin-2- yl)methanone
68
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(pyrrolidin- 1-yl)pyridin-2- yl)methanone
69
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(3- methylisoxazol-5- yl)pyridin-2-yl)methanone
70
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(1H- pyrazol-1-yl)pyridin-2- yl)methanone
71
(±)-(5-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
72
(±)-(4-methyl-3-(2H- 1,2,3-triazol-2-yl)pyridin- 2-yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
73
(±)-(3-(dimethylamino)-6- methylpyridin-2-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
74
(±)-(3-(2H-1,2,3-triazol-2- yl)quinolin-2-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
75
(±)-(7-ethoxyquinolin-8- yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
76
(±)-(3,6- dimethylimidazo[1,2- a]pyridin-5-yl)(2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
77
(±)-(1-methyl-4-phenyl- 1H-pyrazol-3- yl)((1S,2R,4R)-2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
78
(±)-(1-methyl-3-phenyl- 1H-pyrazol-4- yl)((1S,2R,4R)-2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
79
(±)-((3,7- dimethylimidazo[1,2- a]pyridin-8-yl)(2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
80
(±)-(7-methylimidazo[1,2- a]pyridin-8-yl)(2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
81
(±)-(1-methyl-4-phenyl- 1H-pyrazol-5-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
82
(±)-((6-methylimidazo[1,2- a]pyridin-5-yl)(2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
83
(±)-(3-ethoxyisoquinolin- 4-yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
84
(±)-(1-methyl-5-phenyl- 1H-pyrazol-4-yl)(-2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
85
(±)-(6-methyl-3-(4- methylpiperazin-1- yl)pyridin-2-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
86
(±)-(6-methyl-3-(piperazin- 1-yl)pyridin-2-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
87
(±)-(6-methyl-3- morpholinopyridin-2- yl)((1S,2R,4R)-2-((pyridin- 2-yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
88
(±)-(7-methoxyquinolin-8- yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
89
(±)-(2-ethoxynaphthalen-1- yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
90
(±)-(3,6′-dimethyl-[2,3′- bipyridin]-2′-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
91
(±)-(3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
92
(±)-(2-methyl-5- phenylthiazol-4-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
93
(±)-(6-methyl-3-(oxazol-2- yl)pyridin-2-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
94
(±)-(6-methyl-3-(3- methylisoxazol-5- yl)pyridin-2-yl)(2- ((pyridin-2-yloxy)methyl)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
95
(±)-(6-methyl-3-(1H- pyrazol-1-yl)pyridin-2- yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
96
(±)-(6-methyl-3-(4-methyl- 1H-pyrazol-1-yl)pyridin-2- yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
97
(±)-(6-methyl-3- (pyrrolidin-1-yl)pyridin-2- yl)(2-((pyridin-2- yloxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
98
(±)-(3,6′-dimethyl-[2,3′- bipyridin]-2′-yl)(2-(((5- fluoropyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
99
(±)-(2-(((5- fluoropyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(3- methylisoxazol-5- yl)pyridin-2-yl)methanone
100
(±)-(2-(((5- fluoropyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(oxazol-2- yl)pyridin-2-yl)methanone
101
(±)-(2-(((5- fluoropyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(pyrrolidin- 1-yl)pyridin-2- yl)methanone
102
(±)-(2-(((5- fluoropyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(pyrimidin- 2-yl)pyridin-2- yl)methanone
103
(±)-(2-(((5- fluoropyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(4-methyl- 1H-pyrazol-1-yl)pyridin-2- yl)methanone
104
(±)-(2-(((5- fluoropyrimidin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(1H- pyrazol-1-yl)pyridin-2- yl)methanone
105
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
106
(±)-(2,6- dimethoxyphenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
107
(±)-((3-fluoro-2- methoxyphenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
108
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2-methoxy-6-(2H- 1,2,3-triazol-2- yl)phenyl)methanone
109
(±)-(5-fluoro-2-(1H- pyrazol-5-yl)phenyl)(2- (((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
110
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(2-methyl-6-(2H-1,2,3- triazol-2- yl)phenyl)methanone
111
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
112
(±)-(5-chloro-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
113
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methoxy-3-(2H- 1,2,3-triazol-2-yl)pyridin- 2-yl)methanone
114
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(5-methoxy-2-(2H- 1,2,3-triazol-2- yl)phenyl)methanone
115
(±)-(2-fluoro-6-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
116
(±)-(4-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
117
(±)-(3-fluoro-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
118
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
119
(±)-(2-(((5-fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)(4-methoxy-2-(2H- 1,2,3-triazol-2- yl)phenyl)methanone
120
(±)-(5-chloro-2-(2H-1,2,3- triazol-2-yl)phenyl)(2-(((5- fluoropyridin-2- yl)oxy)methyl)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
121
(±)-(2-((4,6- dimethylpyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
122
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((4,6- dimethylpyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
123
(±)-(2-((4,6- dimethylpyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-ethoxy-6- methylpyridin-2- yl)methanone
124
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-(quinoxalin- 2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
125
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-(quinoxalin-2- ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
126
(±)-(3-fluoro-2- methoxyphenyl)(2- (quinoxalin-2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
127
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2- (quinoxalin-2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
128
(±)-(6-methyl-3- (pyrimidin-2-yl)pyridin-2- yl)(2-(quinoxalin-2- ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
129
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((6- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
130
(±)-((2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((4- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
131
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- chloropyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
132
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((6- (trifluoromethyl)pyridazin- 3-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
133
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- methoxypyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
134
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- methylpyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
135
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-(pyridin-2- ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
136
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- chlorobenzo[d]oxazol-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
137
(±)-(2-((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(pyrimidin- 2-yl)pyridin-2- yl)methanone
138
(±)-(2-((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2- methoxyphenyl)methanone
139
(±)-(2((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-ethoxy-6- methylpyridin-2- yl)methanone
140
(±)-(2((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
141
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
142
(±)-(3-fluoro-2- methoxyphenyl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
143
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
144
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2-((5 (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
145
(±)-(6-methyl-3- (pyrimidin-2-yl)pyridin-2- yl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
146
(±)-(3-fluoro-2- methoxyphenyl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
147
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
148
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
149
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2- (quinoxalin-2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
150
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-(quinoxalin-2- ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
151
(±)-(3-fluoro-2- methoxyphenyl)(2- (quinoxalin-2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
152
(±)-(2-((5-bromopryidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
153
(±)-(2-((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-ethoxy-6- methylpyridin-2- yl)methanone
154
(±)-(2-((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2- methoxyphenyl)methanone
155
(±)-((2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((4- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
156
(±)-(2-((5-fluoropyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
157
(±)-(3-fluoro-2- methoxyphenyl)(2-((5- fluoropyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
158
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
159
(2-ethoxynaphthalen-1- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
160
isoquinolin-4- yl((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
161
(4-methoxy-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
162
(2-methoxy-6-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
163
(5-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
164
(5-(4-fluorophenyl)-2- methylthiazol-4- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
165
(3-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
166
(3-ethoxyisoquinolin-4- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
167
(6-methyl-2-(2H-1,2,3- triazol-2-yl)pyridin-3- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
168
(6-methyl-2-(1H-1,2,3- triazol-1-yl)pyridin-3- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
169
(4-methoxy-2-(pyrimidin- 2-yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
170
(1H-benzo[d]imidazol-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
171
(1-methyl-1H- benzo[d]imidazol-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
172
(3-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
173
(4-(difluoromethoxy)-2- (2H-1,2,3-triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
174
(3-fluoro-2-(3-methyl- 1,2,4-oxadiazol-5- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
175
(5-methoxy-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
176
(5-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
177
(4-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
178
(2-fluoro-6-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
179
(6-methylimidazo[2,1- b]thiazol-5-yl)((1S,2R,4R)- 2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
180
(3-fluoro-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
181
(2-((4,6- dimethylpyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2- methoxyphenyl)methanone
182
(3-fluoro-2-(pyridazin-3- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
183a
(3-methyl-2-(pyridazin-3- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
183b
(3-fluoro-2-(pyridazin-4- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
184
(3-fluoro-2-(pyrazin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
185
(3-methyl-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
186
(4-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
187
(3-fluoro-2-(pyridin-4- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
188
(3-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
189
((1S,2R,4R)-2-((3- bromoimidazo[1,2- a]pyrazin-8-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2-(pyrimidin- 2-yl)phenyl)methanone
190
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
191
(3-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
192
(3-methyl-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
193
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((3-(trifluoromethyl)- [1,2,4]triazolo[4,3- a]pyrazin-8-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
194
methyl 5-(((1S,2R,4R)-7- (3-fluoro-2-(pyrimidin-2- yl)benzoyl)-7- azabicyclo[2.2.1]heptan-2- yl)amino)pyrazine-2- carboxylate
195
(2-iodo-3- methylphenyl)((1S,2R,4R)- 2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
196
(3-fluoro-2- iodophenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
197
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5-methylpyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
198
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
199
(4-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
200
(3-methyl-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
201
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- (methyl(5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
202
(3-methyl-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
203
(3-fluoro-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
204
(±)-(3-fluoro-2-(pyrimidin- 2-yl)phenyl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
205
(±)-(3-fluoro-2-(pyrimidin- 2-yl)phenyl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
206
(3-ethoxy-6-methylpyridin- 2-yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
207
(3-(2H-1,2,3-triazol-2- yl)pyridin-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
208
(2-methoxy-6-(pyrimidin- 2-yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
209
(2-fluoro-6-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
210
(7-ethoxyquinolin-8- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
211
(2-(1,4-dimethyl-1H- pyrazol-5-yl)-6- methoxyphenyl)((1S,2R, 4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
212
(3-methyl-2-(pyridin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
213
(3-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
214
(3-methyl-2-(2H-1,2,3 triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
215
(3-methyl-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
216
(±)-(2-((4,6- dimethylpyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
217
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((4,6- dimethylpyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
218
(±)-(2-((4,6- dimethylpyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-ethoxy-6- methylpyridin-2- yl)methanone
219
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-(quinoxalin- 2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
220
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-(quinoxalin-2- ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
221
(±)-(3-fluoro-2- methoxyphenyl)(2- (quinoxalin-2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
222
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2- (quinoxalin-2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
223
(±)-(6-methyl-3- (pyrimidin-2-yl)pyridin-2- yl)(2-(quinoxalin-2- ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
224
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((6- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
225
(±)-((2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((4- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
226
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- chloropyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
227
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((6- (trifluoromethyl)pyridazin- 3-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
228
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- methoxypyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
229
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- methylpyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
230
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-(pyridin-2- ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
231
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- chlorobenzo[d]oxazol-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
232
(±)-(2-((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(pyrimidin- 2-yl)pyridin-2- yl)methanone
233
(±)-(2-((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2- methoxyphenyl)methanone
234
(±)-(2-((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-ethoxy-6- methylpyridin-2- yl)methanone
235
(±)-(2-((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
236
(±)-(2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
237
(±)-(3-fluoro-2- methoxyphenyl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
238
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
239
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
240
(±)-(6-methyl-3- (pyrimidin-2-yl)pyridin-2- yl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
241
(±)-(3-fluoro-2- methoxyphenyl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
242
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
243
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
244
(±)-(3-ethoxy-6- methylpyridin-2-yl)(2- (quinoxalin-2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
245
(±)-(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)(2-(quinoxalin-2- ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
246
(±)-(3-fluoro-2- methoxyphenyl)(2- (quinoxalin-2-ylamino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
247
(±)-(2((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
248
(±)-(2-((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-ethoxy-6- methylpyridin-2- yl)methanone
249
(±)-(2((5-bromopyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2- methoxyphenyl)methanone
250
(±)-((2-(2H-1,2,3-triazol-2- yl)phenyl)(2-((4- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
251
(±)-(2-((5-fluoropyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)methanone
252
(±)-(3-fluoro-2- methoxyphenyl)(2-((5- fluoropyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)methanone
253
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
254
(2-ethoxynaphthalen-1- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
255
isoquinolin-4- yl((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
256
(4-methoxy-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
257
(2-methoxy-6-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
258
(5-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
259
(5-(4-fluorophenyl)-2- methylthiazol-4- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
260
(3-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
261
(3-ethoxyisoquinolin-4- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
262
(6-methyl-2-(2H-1,2,3- triazol-2-yl)pyridin-3- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
263
(6-methyl-2-(1H-1,2,3- triazol-1-yl)pyridin-3- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
264
(4-methoxy-2-(pyrimidin- 2-yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
265
(1H-benzo[d]imidazol-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
266
(1-methyl-1H- benzo[d]imidazol-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
267
(3-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
268
(4-(difluoromethoxy)-2- (2H-1,2,3-triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
269
(3-fluoro-2-(3-methyl- 1,2,4-oxadiazol-5- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
270
(5-methoxy-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
271
(5-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
272
(4-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
273
(2-fluoro-6-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
274
(6-methylimidazo[2,1- b]thiazol-5-yl)((1S,2R,4R)- 2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
275
(3-fluoro-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
276
(2-((4,6- dimethylpyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2- methoxyphenyl)methanone
277
(3-fluoro-2-(pyridazin-3- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
278
(3-methyl-2-(pyridazin-3- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
279
(3-fluoro-2-(pyridazin-4- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
280
(3-fluoro-2-(pyrazin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
281
(3-methyl-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
282
(4-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
283
(3-fluoro-2-(pyridin-4- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
284
(3-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
285
((1S,2R,4R)-2-((3- bromoimidazo[1,2- a]pyrazin-8-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2-(pyrimidin- 2-yl)phenyl)methanone
286
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
287
(3-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
288
(3-methyl-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
289
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((3-(trifluoromethyl)- [1,2,4]triazolo[4,3- a]pyrazin-8-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
290
methyl 5-(((1S,2R,4R)-7- (3-fluoro-2-(pyrimidin-2- yl)benzoyl)-7- azabicyclo[2.2.1]heptan-2- yl)amino)pyrazine-2- carboxylate
291
(2-iodo-3- methylphenyl)((1S,2R,4R)- 2-((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
292
(3-fluoro-2- iodophenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
293
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5-methylpyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
294
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
295
(4-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
296
(3-methyl-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
297
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1R,2S,4S)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
298
(3-fluoro-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
299
(3-methyl-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
300
(3-chloro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
301
((1S,2R,4R)-2-((5- bromopyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-fluoro-2-(oxazol-2- yl)phenyl)methanone
302
((1S,2R,4R)-2-((5- bromopyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-methyl-2-(oxazol- 2-yl)phenyl)methanone
303
((1S,2R,4R)-2-((5- bromopyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-fluoro-2- (pyrimidin-2- yl)phenyl)methanone
304
((1S,2R,4R)-2-((5- bromopyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-methyl-2- (pyrimidin-2- yl)phenyl)methanone
305
((1S,2R,4R)-2-((5- bromopyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
306
((1S,2R,4R)-2-((5- bromopyridin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-methyl-2-(2H- 1,2,3-triazol-2- yl)phenyl)methanone
307
((1S,2R,4R)-2-((5- bromopyrazin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-fluoro-2-(oxazol-2- yl)phenyl)methanone
308
((1S,2R,4R)-2-((5- bromopyrazin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-methyl-2-(oxazol- 2-yl)phenyl)methanone
309
((1S,2R,4R)-2-((5- bromopyrazin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-fluoro-2- (pyrimidin-2- yl)phenyl)methanone
310
((1S,2R,4R)-2-((5- bromopyrazin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-methyl-2- (pyrimidin-2- yl)phenyl)methanone
311
((1S,2R,4R)-2-((5- bromopyrazin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
312
((1S,2R,4R)-2-((5- bromopyrazin-2-yl)amino)- 7-azabicyclo[2.2.1]heptan- 7-yl)(3-methyl-2-(2H- 1,2,3-triazol-2- yl)phenyl)methanone
313
((1S,2R,4R)-2-((5- bromopyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2-(oxazol-2- yl)phenyl)methanone
314
((1S,2R,4R)-2-((5- bromopyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-methyl-2-(oxazol-2- yl)phenyl)methanone
315
((1S,2R,4R)-2-((5- bromopyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2-(pyrimidin- 2-yl)phenyl)methanone
316
((1S,2R,4R)-2-((5- bromopyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-methyl-2-(pyrimidin- 2-yl)phenyl)methanone
317
((1S,2R,4R)-2-((5- bromopyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
318
((1S,2R,4R)-2-((5- bromopyrimidin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)(3-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)methanone
319
(3-methyl-2-(pyridin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
320
(3-fluoro-2-(pyridin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
321
(3-fluoro-2-(pyridin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
322
(3-methyl-2-(pyridin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
323
(3-fluoro-2-(pyridin-2- yl)phenyl)((2S)-2-((5- (trifluoromethyl)pyrazin-2- yl)amino)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
324
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
325
(2-methoxy-6-(pyrimidin- 2-yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
326
(5-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
327
(4-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
328
(3-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
329
(5-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
330
(2-fluoro-6-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
331
(2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
332
(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
333
(3-methyl-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
334
(3-methyl-2-(pyridin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
335
(2-(5-fluoropyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
336
(2-fluoro-6-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
337
(5-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
338
(2-bromo-3- fluorophenyl)((1S,2R,4R)- 2-((5- (trifluoromethyl)pyridin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
339
(3-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
340
(2-methoxy-6-(pyrimidin- 2-yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
341
(5-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
342
(4-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
343
(3-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
344
(5-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
345
(2-fluoro-6-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
346
(2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
347
(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
348
(3-methyl-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
349
(3-methyl-2-(pyridin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
350
(2-(5-fluoropyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
351
(2-fluoro-6-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
352
(5-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
353
(2-bromo-3- fluorophenyl)((1S,2R,4R)- 2-((5- (trifluoromethyl)pyrazin-2- yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
354
(2-methoxy-6-(pyrimidin- 2-yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
355
(5-fluoro-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
356
(4-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
357
(3-methyl-2-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
358
(5-fluoro-2-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
359
(2-fluoro-6-(pyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
360
(2-(2H-1,2,3-triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
361
(6-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
362
(3-methyl-2-(oxazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
363
(3-methyl-2-(pyridin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
364
(2-(5-fluoropyrimidin-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
365
(2-fluoro-6-(2H-1,2,3- triazol-2- yl)phenyl)((1S,2R,4R)-2- ((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
366
(5-methyl-3-(2H-1,2,3- triazol-2-yl)pyridin-2- yl)((1S,2R,4R)-2-((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone
367
(2-bromo-3- fluorophenyl)((1S,2R,4R)- 2-((5- (trifluoromethyl)pyrimidin- 2-yl)oxy)-7- azabicyclo[2.2.1]heptan-7- yl)methanone

748 more elements

Dependencies are inferred from the claim text.

Substituted 7-azabicyles and their use as orexin receptor modulators

Life of this patent

Substituted 7-azabicyles and their use as orexin receptor modulators

Life of this patent

Abstract

Claims91