Dyrk1 inhibitors and uses thereof

A compound of formula (I):

• wherein:
• X is a nitrogen atom;
• Y is an oxygen atom, a sulfur atom, a NH group or a N—(C1-C3)alkyl group;
• R1 is a —C(=A)-B group, wherein:
• A is NH or O and
• B is a OR5 or a NR5R6 group, wherein:
• R5 and R6 are independently chosen from a hydrogen atom and an unsubstituted or substituted C1-C8 alkyl group;
• A and B can alternatively independently be nitrogen and/or oxygen atoms and form, with the carbon atom to which they are bound, a heterocycloalkyl group;
• R2 is a hydrogen atom or an unsubstituted C1-C8 alkyl group;
• R3 is an unsubstituted or substituted C1-C8 alkyl or an unsubstituted or substituted aryl or heteroaryl group;
• R4 is a hydrogen atom, a halogen atom, an amino group, a cyano group or an unsubstituted or substituted C1-C5 alkyl group;
• R7 and R8 are independently chosen from a hydrogen atom, a halogen atom, a hydroxyl group, or an unsubstituted or substituted C1-C5 alkyl group and pharmaceutically acceptable salts thereof.

A compound of formula (III), (VI) or (VII):

• wherein:
• R7 and R8 are independently chosen from a hydrogen atom, a halogen atom, a hydroxyl group, or an unsubstituted or substituted C1-C5 alkyl group and pharmaceutically acceptable salts thereof,
• Hal is a halogen atom, and
• (PG) is an amino protecting group.