Compounds for the treatment of neurologic disorders
OwnerDavid Steven Menaldino, George Walter Koszalka +2inventors
InventorsDavid Steven Menaldino, George Walter Koszalka, Ruppa Poornachary Kamalesh Babu, Scott James Myers
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Abstract
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of certain neurologic disorders, including disorders related to NMDA receptor activity, including neuropsychiatric disorders, neurodegenerative disorders and other neurologic diseases, disorders and conditions including stroke, brain injury, epilepsy, neuropsychiatric disorders, mood disorders, chronic pain and related conditions.
Claims18
A compound of Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof:
- wherein:
- each X is independently C1-6 alkyl, C1-6 alkoxyl, C(═O)—C1-6 alkyl, C1-6 haloalkyl, C3-6 cycloalkyl, hydroxyl, halo, nitro or cyano;
- k is 0, 1, 2, 3, 4, or 5;
- Z is CH or N;
- L is —NR1—(CR3R4)n—NR2—, —(CR3R4)n—NR2—, —O—(CR3R4)n—NR2—,
- wherein each R1 and R2 is independently H, C1-6 alkyl, C2-6 alkenyl, or C6-12 aralkyl;
- each R3 and R4 is independently H, C1-6 alkyl, C2-6 alkenyl, C6-12 aralkyl, C1-6 alkoxyl, C(═O)—C1-6 alkyl, C1-6 haloalkyl, hydroxyl, halo, nitro or cyano;
- or CR3R4 is C═O;
- n is 1, 2, 3, or 4;
- M is —CH—CH(OH)— or —CH(CH2OH)—;
- Y is
- wherein R5 is H or C1-6 alkyl.
Dependencies are inferred from the claim text.