Compositions of a polyorthoester and an aprotic solvent
AssigneeHeron Therapeutics, Inc.
InventorsThomas B. Ottoboni, Lee Ann Lynn Schillinger, Joseph Niemann
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Abstract
Delivery systems and compositions comprised of a biodegradable polyorthoester polymer, an aprotic solvent, and a drug are described. The solvent is selected to modulate release of drug from the composition, where, in some embodiments, the solvent is rapidly released after administration and provides a corresponding rapid rate of drug release. Alternatively, in other embodiments, the solvent is slowly released from the composition after its administration, and provides a correspondingly slow rate of drug release.
Claims25
A delivery system, comprising:
- a polyorthoester;
- an aprotic solvent in which the polyorthoester is miscible to form a single phase;
- and
- a therapeutically active agent dispersed or solubilized in the single phase;
- wherein the active agent is released from the system over a period of between approximately 1 day and approximately 8 weeks.
A flowable composition, comprising:
- a polyorthoester;
- a solvent in which the polyorthoester is miscible to form a single phase;
- and
- a therapeutically active agent dispersed or solubilized in the single phase;
- wherein the solvent is an aprotic solvent with a dipole moment greater than about 2 Debye (D).
A method of treatment, comprising:
- dispensing from a needle a composition comprised of a polyorthoester, an aprotic solvent in which the polyorthoester is miscible to form a single phase;
- and a therapeutically active agent dispersed or solubilized in the single phase;
- wherein the solvent is selected to achieve a controlled release of the active agent from the composition according to a predetermined release profile, and wherein the release of the active agent is for a period of between approximately 1 day and approximately 8 weeks.
Dependencies are inferred from the claim text.