Abuse deterrent compositions and methods of use
AssigneeInspirion Delivery Technologies, LLC
InventorsManish S. Shah, Ray J. DiFalco, Stefan Aigner
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Abstract
Orally administrable pharmaceutical compositions, methods of administration, and methods of making the same are provided. The pharmaceutical compositions provide abuse deterrent properties.
Claims30
An orally administrable pharmaceutical composition comprising a drug, wherein the composition is configured such that when the pharmaceutical composition is administered intranasally in physically compromised form to a subject, the sum of the area under the curve (AUC) of the drug and the AUC of a major metabolite of the drug after a period of time is less than the sum of the AUC of the drug and the AUC of the major metabolite achieved after the same period of time after oral administration of the pharmaceutical composition in an intact form.
An orally administrable pharmaceutical composition comprising 60 mg of morphine or a salt thereof, wherein the composition is configured such that when the pharmaceutical composition is administered intranasally in physically compromised form to a subject, the sum of the area under the curve (AUC) of morphine and the AUC of morphine-6-glucuronide (M6G) after a period of time is less than about 900 ng·h/mL.
An orally administrable pharmaceutical composition comprising morphine or a salt thereof, wherein the composition is configured such that when the pharmaceutical composition is administered intranasally in physically compromised form to a subject, the sum of the area under the curve (AUC) of morphine and the AUC of morphine-6-glucuronide (M6G) after a period of time is less than about 20 ng·h/mL/mg (ng·h/mL per mg of morphine).
An orally administrable pharmaceutical composition comprising a drug, wherein the composition is configured such that when the pharmaceutical composition is administered intranasally in physically compromised form to a subject, the ratio of the area under the curve (AUC) of the drug to the AUC of a major metabolite of the drug (drug:major metabolite) achieved after a period of time is about 10 or less.
Dependencies are inferred from the claim text.