1,2,5-substituted benzimidazoles as flap modulators

A compound of Formula (I)

• wherein:
• R1 is
• Ra is H, F, or Cl;
• Rb is H, F, or Cl;
• Rc is H, or F;
• is a ring selected from the group consisting of
• R2 is H, Br, Cl, F, —CN, —CH2CN, OCF3, CF3, CH3, pyrrolyl, pyridyl, pyrazolyl, pyrimidyl, pyridyl, thiazolyl, isoxazolyl, 1,2,3-triazolyl, furanyl, 3,5-dimethylisoxazol-4-yl, 5-methyl-1,2,4-oxadiazol-3-yl, —CH2-(3,3-difluoropiperidin-1-yl), azetidin-1-yl, 3,3-difluoroazetidin-1-yl, pyrrolidinyl, 3,3-difluoropyrrolidin-1-yl, piperidin-1-yl, 4-trifluoromethylpiperidin-1-yl, 3,3-difluoropiperidin-1-yl, 4,4-difluoropiperidin-1-yl, morpholin-1-yl, 1,2-difluoro-phen-4-yl or phenyl, wherein said phenyl is optionally substituted with one substituent selected from the group consisting of F, CH3, CF3, CH(CH3)2, —CN, CH3SO2—, CH3SO2NH—, NH2SO2—, NH2C(O)—, CH3C(O)NH, and CH3O—;
• and said pyrazolyl is optionally substituted with methyl, and said pyrimidyl and said pyridyl are optionally substituted with one or two substituents selected from the group consisting of —OC(1-2)alkyl, —N(CH3)2, and CF3;
• R3 is H, Br, Cl, F, —CN, —CH2CN, OCF3, CF3, CH3, pyrrolyl, pyridyl, pyrazolyl, pyrimidyl, pyridyl, thiazolyl, isoxazolyl, 1,2,3-triazolyl, furanyl, 3,5-dimethylisoxazol-4-yl, 5-methyl-1,2,4-oxadiazol-3-yl, —CH2-(3,3-difluoropiperidin-1-yl), azetidin-1-yl, 3,3-difluoroazetidin-1-yl, pyrrolidinyl, 3,3-difluoropyrrolidin-1-yl, piperidin-1-yl, 4-trifluoromethylpiperidin-1-yl, 3,3-difluoropiperidin-1-yl, 4,4-difluoropiperidin-1-yl, morpholin-1-yl, 1,2-difluoro-phen-4-yl or phenyl, wherein said phenyl is optionally substituted with one substituent selected from the group consisting of F, CH3, CF3, CH(CH3)2, —CN, CH3SO2—, CH3SO2NH—, NH2SO2—, NH2C(O)—, CH3C(O)NH, and CH3O—;
• and said pyrazolyl is optionally substituted with methyl, and said pyrimidyl and said pyridyl are optionally substituted with one or two substituents selected from the group consisting of —OC(1-2)alkyl, —N(CH3)2, and CF3;
• R4 is H, F, CF3, OCF3, Cl, Br, —CN, HO2C-phen-3-yl, 2-trifluoromethyl-pyrid-5-yl, or CH3;
• Rd is H, or F;
• R5 is
• R6 is H, CH3, or CH2CH3;
• and solvates, hydrates, and pharmaceutically acceptable salts thereof.