Cgrp receptor antagonists
AssigneeMerck Sharp & Dohme Corp.
InventorsCraig A. Stump, Amy G. Quigley, Cory R. Theberge, Michael R. Wood
Life of this patent
Estimating the term…
Abstract
Compounds of Formula I: (wherein variables A1, A2, A3, ring-B, m, n, J, E1, E2, E3, R5, RPG and Y are as described herein), which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (I) and the use of these compounds and compositions in the prevention or treatment of diseases in which CGRP receptors are involved.
Claims8
1-17. (canceled)
The following compounds:
- or a pharmaceutically acceptable salt thereof.
A compound of formula (VA)
- wherein Rb is selected from the group consisting of
- or a pharmaceutically acceptable salt thereof, or the compound of formula (V) is a compound of formula (VB)
- wherein Rb is
- or a pharmaceutically acceptable salt thereof.
A compound of formula:
- wherein Rb is
- or a pharmaceutically acceptable salt thereof.
A method of treating headache in a mammalian patient in need of such treatment, which comprises administering to the patient a therapeutically effective amount of the compound of claim 1, or a pharmaceutically acceptable salt thereof.
24-25. (canceled)
Dependencies are inferred from the claim text.