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US 2014/0275007 A1Published application
Oxamazin antibiotics
OwnerTomasz Glinka, Scott Hecker +1inventors
InventorsTomasz Glinka, Scott Hecker, Olga Rodny
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Abstract
Disclosed herein are oxamazin monobactam compounds and their use as antibiotics resistant to degradation by β-lactamases. Also disclosed are pharmaceutical compositions containing the compounds and methods of synthesis.
Claims25
A compound having the structure of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 and R2 are independently selected from the group consisting of H, halide, CN, C1-3 alkyl, —X(C1-3 alkyl), —(C1-3 alkyl)OH, —(C1-3 alkyl)CN and C1-3 haloalkyl, or alternatively R1 and R2 together with the atom to which they are attached form a three to four membered carbocyclic ring optionally substituted with one or more halide, or a four membered heterocyclic ring;
- R3 and R4 are independently selected from the group consisting of halide, CN, C1-3 alkyl, —X(C1-3 alkyl), —X(C1-3 haloalkyl), —(C1-3 alkyl)OH, —(C1-3 alkyl)CN and C1-3 haloalkyl, or alternatively R3 and R4 together with the atom to which they are attached form a three to four membered carbocyclic ring optionally substituted with one or more halide, or a four membered heterocyclic ring;
- R5 and R6 are independently selected from the group consisting of H, halide, CN, C1-3 alkyl, —X(C1-3 alkyl), —X(C1-3 haloalkyl), —(C1-3 alkyl)OH, —(C1-3 alkyl)CN and C1-3 haloalkyl, or alternatively R5 and R6 together with the atom to which they are attached form a three to four membered carbocyclic ring optionally substituted with one or more halide, or a four membered heterocyclic ring;
- A is selected from the group consisting of C—H, C-halide, and N;
- and
- each X is independently selected from O or S.
4 more elements
Dependencies are inferred from the claim text.