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US 2014/0274999 A1Published application
Cephalosporin compositions and methods of manufacture
OwnerJan-Ji Lai, Pradip M. Pathare +2inventors
InventorsJan-Ji Lai, Pradip M. Pathare, Laxma Kolla, Adrien F. Soret
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Abstract
Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.
Claims16
A method for preparing a compound of formula (II-1), or a salt thereof,
- comprising the step of reacting a compound of formula (III-1), or a salt thereof,
- with a compound of formula (IV-1), or a salt thereof,
- in a mixture comprising an organic solvent and about 6-9 percent (w/w) of water relative to the compound of formula (III-1), or salt thereof.
A composition comprising two or more compounds selected from the group consisting of:
- (a) the compound of formula (II-1), or a salt thereof
- (b) the compound of formula (III-1), or a salt thereof
- and
- (c) the compound of formula (IV-1), or a salt thereof
1 more element
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.