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US 2014/0274996 A1Published application
Tazobactam and ceftolozane antibiotic compositions
OwnerNicole Miller Damour, Joseph Terraccianoinventors
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Abstract
This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of making those compositions, and related methods and uses of these compositions.
Claims2
A method of lyophilizing a CXA-101 pharmaceutical composition comprising the steps of:
- a. combining in a vessel chamber water, citric acid, maltose, sodium bicarbonate and CXA-101 to form a solution;
- b. adjusting the pH of the solution to about 6;
- c. changing the temperature of the vessel to about −40° C. and maintaining until contents of the vessel freeze;
- d. changing the temperature of the vessel to −20° C.;
- e. changing the chamber pressure from 100 to 150 mTorr;
- f. monitoring the temperature of the contents of the vessel;
- g. changing the vessel temperature to 30° C.;
- h. changing the chamber pressure to not more than 10 mTorr;
- i. maintaining the contents of the chamber for a time sufficient to complete lyophilization of the contents of the chamber;
- j. returning the chamber pressure to atmospheric pressure with sterilized nitrogen;
- and
- k. stoppering the vessels completely.
9 more elements
Dependencies are inferred from the claim text.