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US 2014/0274972 A1Published application
Compositions and Methods employing Wolbachia FtsZ as a target for Albendazole sulfone
AssigneeThe Regents of the University of California
InventorsLaura Serbus, Fredric Landmann, Catharina Lindley, Pamela White, William Sullivan
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Abstract
Compositions and Methods are described in which Albendazole sulfone binds to Wolbachia FtsZ providing anti filarial activity.
Claims15
A method for treating Wolbachia-related disease in a subject, the method comprising administering to the subject a formulation comprising an Albendazole compound sulfone.
(canceled)
A method for treating or preventing Wolbachia-related disease comprising the following steps:
- (1) providing an anti-Wolbachia formulation wherein the formulation comprises at least one compound selected from the group consisting of Albendazole, Albendazole derivatives, metabolites, precursors, pro-drugs and variants thereof, either singly or in combination;
- (2) providing a subject in need of treatment or prevention of a Wolbachia-related disease;
- (3) providing to the subject a therapeutically effective amount of the anti-Wolbachia formulation, whereby such treatment results in the measurable killing of Wolbachia in vivo;
- and (4) determining the clinical effect of said treatment.
1 more element
A pharmaceutical formulation for treating Wolbachia-related disease comprising Albendazole sulfone.
Dependencies are inferred from the claim text.