Systems and Methods of Using Chemically Bound Antibiotics Activated by Infections
AssigneeOsteoceramics, Inc.
InventorThomas D. McGee
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Abstract
Methods, devices and systems are disclosed for chemically bonding antibiotics to selected substrate materials which are not dissolved in normal physiological processes so that high local concentrations can be achieved during the inflammatory response. The antibiotics will remain permanently bonded to the substrate material until an infection occurs which releases the antibiotic in high concentrations to help control the infection. The high local concentrations may be much higher than systemic toxic levels, and can never reach toxic levels because the local dose is much less than needed to reach systemic toxicity if completely dissolved.
Claims36
A drug delivery system comprising:
- a biologically active material chemically bonded to a substrate, wherein the substrate is adapted for insertion into a patient during a medical procedure;
- wherein the biologically active material is inactive for pharmaceutical purposes while bonded to the substrate;
- wherein the biologically active materials is released from the substrate by breakage of the chemical bond upon the occurrence of a local infection near the substrate to become pharmaceutically active and fight the local infection.
A method of using a drug delivery system, said method comprising:
- chemically bonding a biologically active material to a substrate with a chemical bond wherein the biologically active material is inactive for pharmaceutical purposes while bonded to the substrate;
- inserting the substrate into a patient during a medical procedure;
- wherein the biologically active material is released from the substrate by breakage of the chemical bond upon the occurrence of a local infection near the substrate to activate the biologically active material and fight the local infection.
A method of using a drug delivery system, said method comprising:
- chemically bonding an antibiotic material to a substrate with a chemical bond wherein the antibiotic remains permanently bonded to the substrate at a pH of above about 7.0;
- inserting the substrate into a patient during a medical procedure;
- wherein the chemical bond is broken when the pH drops below about 5.0 upon the occurrence of a local infection near the substrate to activate the antibiotic and fight the local infection.
A method of using a drug delivery system, said method comprising
- chemically bonding an antibiotic material to a substrate with a chemical bond wherein the antibiotic remains permanently bonded to the substrate at a pH of about 7.0;
- inserting the substrate into a patient during a medical procedure;
- wherein the chemical bond is broken using enzymes and humoral components from a local infection near the substrate to activate the antibiotic and fight the local infection.
Dependencies are inferred from the claim text.