Use of minocycline for therapeutic treatment of acute spinal cord injuries
AssigneeRick Hansen Institute
InventorsSteven CASHA, John HURLBERT, Voon Wee YONG
Life of this patent
Estimating the term…
Abstract
A dosing regime for providing therapy for a neurological trauma such as spinal cord injury in a human subject. The dosing regime comprises intravenous administration of a plurality of minocycline doses for a 7-day period at 12-h intervals such that a steady state level of minocycline is reached and maintained in a subject's serum and/or cerebrospinal fluid after administration of three minocycline doses. An initial minocycline dose of at least 800 mg is preferably administered within 12 h after an occurrence of the neurological trauma. The minocycline dosage is sequentially tapered to 400 mg and then maintained at 400 mg for the remainder of the 7-day treatment period.
Claims17
A dosing regime for providing a therapy for a neurological trauma in a human subject in need thereof, the dosing regime comprising:
- administration of a plurality of minocycline doses for a 7-day period wherein an initial minocycline dose is administered within about 12 h after an occurrence of the neurological trauma and the remainder of the plurality of minocycline doses are administered at 12-h intervals;
- wherein a steady state level of minocycline is detectable in the subject's serum after administration of three minocycline doses, said steady state minocycline level in the subject's serum in a range of about 7 μg/ml to about 17.5 μg/ml.
A method for treating a neurological trauma in a human subject, comprising:
- intravenously administering to the subject a plurality of minocycline doses for a 7-day period wherein an initial minocycline dose is administered within about 12 h after an occurrence of the neurological trauma and the remainder of the plurality of minocycline doses are administered at 12-h intervals;
- collecting a plurality of blood samples from the subject;
- separating a serum sample from each of said plurality of blood samples;
- assaying each of the serum samples to determine a level of minocycline in each of the serum samples;
- and
- adjusting one or more of said plurality of minocycline doses to maintain a steady state level of minocycline in the subject's serum in a range of about 7 μg/ml to about 10 μg/ml.
Dependencies are inferred from the claim text.