Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis
OwnerLeslie B. Gordon, Mark W. Kieran +1inventors
InventorsLeslie B. Gordon, Mark W. Kieran, Monica E. Kleinman
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Abstract
Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin, and inhibit farnesyl biosynthesis, lamin A prenylation, and increase progerin clearance.
Claims20
A method for treating a progeroid disease or condition, a cellular aging-related condition, a bone disease or condition, or a cardiovascular disease or condition, the method comprising:
- administering to a patient in need of such treatment a therapeutically effective amount of at least three active ingredients comprising:
- a farnesyltransferase inhibitor (FTI);
- a statin;
- and
- an aminobisphosphonate.
A method for treating a progeroid disease or condition, a cellular aging-related condition, a bone disease or condition, or a cardiovascular disease or condition, the method comprising:
- administering to a patient in need of such treatment a therapeutically effective dose of at least four active ingredients comprising:
- a farnesyltransferase inhibitor (FTI);
- a statin;
- an aminobisphosphonate;
- and
- an mTOR inhibitor.
Dependencies are inferred from the claim text.