Lipidomics of familial longevity
AssigneesUniversiteit Leiden, Academisch Ziekenhuis Leiden (H.O.D.N. Lumc)
InventorsPieternella Slagboom, Thomas Hankemeier
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Abstract
The disclosure relates to method of typing a sample from an individual as a sample from an individual with an increased life expectancy, an average life expectancy or a reduced life expectancy. The typing is based on a comparison of a level of lipid species in a sample of the individual to a level of lipid species in a reference. The disclosure further relates to a composition comprising lipid species for use in increasing life expectancy of an individual.
Claims17
A method of typing a sample from an individual, comprising:
- determining a level of at least one lipid species in a relevant sample from the individual, comparing said level with a reference;
- and
- typing said sample as a sample from an individual with an increased life expectancy, an average life expectancy or a reduced life expectancy on the basis of said comparison.
A composition comprising PC (O-36:2), PC (O-36:3), SM (d18:1/14:0);
- SM (d18:1/15:0);
- SM (d18:1/12:0) and/or SM (d18:1/23:1), for use in increasing plasma levels of PC (O-36:2), PC (O-36:3), SM (d18:1/14:0);
- SM (d18:1/15:0);
- SM (d18:1/12:0) and/or SM (d18:1/23:1).
A composition comprising increased levels of PC (O-36:2), PC (O-36:3), SM (d18:1/14:0);
- SM (d18:1/15:0);
- SM (d18:1/12:0) and/or SM (d18:1/23:1) for use in increasing life expectancy of an individual.
(canceled)
Dependencies are inferred from the claim text.