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US 2014/0274950 A1Published application
Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders
AssigneeMedical University of South Carolina
InventorsCraig C. BEESON, Christopher C. LINDSEY, Yuri K. PETERSON, Baerbel ROHRER
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Abstract
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
Claims18
The compound according to formula (I):
- wherein:
- R1 is lower alkyl, trimethylsilyl or pyridinyl;
- one of R2 or R2′ is absent and the other is —CH2R3 or —CH2C(O)R3;
- and
- R3 is pyridinyl, 1H-indol-3-yl, unsubstituted phenyl or phenyl mono-, bi- or tri-substituted independently with alkoxy,
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.