Compounds and compositions for the treatment of parasitic diseases

A compound of Formula I:

• or a pharmaceutical acceptable salt, or a stereoisomer thereof;
• wherein
• X is O or NR4, wherein R4 is selected from hydrogen, C1-4alkyl, haloC1-4alkyl, and —C(O)R10, wherein R10 is hydroxy, C1-4alkyl, C1-4alkoxy, amino, C1-4alkylamino, C3-6cycloalkyl and C4-6heterocycloalkyl, each of which is independently optionally substituted by 1-2 substituents independently selected from hydroxyl, halo and C1-4alkyl;
• L1 is —C(O)— or —S(O)2—;
• R1 is selected from nitro, C1-4alkyl, C1-6alkoxy, amino, C6-3heteroaryl, C3-6cycloalkyl and C4-6heterocycloalkyl, each of which is optionally substituted by 1-2 substituent independently selected from halo, cyano, amino, C1-4alkyl, haloC1-4alkyl, C1-6alkoxy, and C1-4alkylcarbonyl;
• or —NHL1R1 is nitro;
• R3 is selected from hydrogen, halo, cyano, C1-4alkyl and haloC1-4alkyl;
• L2 is selected from a bond, —C(O)— and —S(O)2—;
• R2 is selected from hydrogen, C1-6alkyl, C1-4alkoxy, amino, C3-6cycloalkyl, C4-6heterocycloalkyl, and C5-6heteroaryl;
• wherein
• the C1-6alkyl, C1-4alkoxy, C3-6cycloalkyl, and amino of R2 are each optionally substituted by 1-2 substituents independently selected from halo, hydroxy, C1-4alkyl, C1-4alkoxy, —NR9aR9b, C3-6cycloalkyl, C5-6heterocycloalkyl, phenyl and C5-6heteroaryl, wherein R9a is hydrogen or C1-4alkyl and R9b is selected from hydrogen, C1-4alkyl, C1-4alkylcarbonyl and C1-4alkoxycarbonyl, and the C5-6heterocycloalkyl, phenyl or C5-6heteroaryl is further optionally substituted by 1-2 substituents independently selected from hydroxyl, C1-4alkyl and C1-4alkoxycarbonyl;
• the C5-6heteroaryl of R2 is optionally substituted with 1-2 substituents selected from hydroxy, C1-4alkyl, and C1-4alkoxycarbonyl;
• the C3-6cycloalkyl or C4-6heterocycloalkyl of R2 are each independently optionally substituted by 1-2 substituents independently selected from halo, cyano, hydroxy, C1-4alkyl, haloC1-4alkyl, C1-4alkoxylC1-4alkyl, aminocarbonyl, C1-4alkoxycarbonyl, and C1-4alkoxycarbonylaminoC1-4alkyl;
• R5 is hydrogen or C1-4alkyl;
• or R2 and R5 together with L2 and N to which R2 and R5, respectively, attached are taken together to form a heteroC5-6cycloalkyl or a heteroC5-6cycloalkenyl, each of which is optionally substituted by 1 to 3 substituents independently selected from oxo, C1-4alkyl, —(CH2)1-4OH, —(CH2)1-4NRaRb, wherein Ra and Rb are each independently hydrogen, C1-4alkyl or C3-6cycloalkyl;
• or —N(R5)L2R2 is nitro or —N═CHN(CH3)2.