Back to results
US 2014/0274923 A1Published application
Mirnas as a prognostic biomarker in pediatric heart failure
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsCarmen Sucharov, Brian Stauffer, Shelley Miyamoto
Life of this patent
Estimating the term…
Abstract
The present invention provides for methods of predicting progression of pediatric heart failure using miRNA biomarkers, as well as subsequent treatment of patients based on their classification.
Claims14
A method of identifying a pediatric subject having dilated cardiomyopathy (DCM) that will recover without heart transplant comprising:
- (a) obtaining an miRNA-containing sample from said patient;
- (b) measuring the levels of one or more miRNAs selected from the group consisting of hsa-miR-135b#/*, hsa-miR-646, hsa-miR-623, hsa-miR-571, hsa-miR-155, hsa-miR-628-5p, hsa-miR636 and hsa-miR-375;
- and
- (c) identifying said patient as one that will recover without heart transplant when one or more of hsa-miR-135b#/*, hsa-miR-646, hsa-miR-623, and hsa-miR-571 are increased as compared levels from a subject requiring heart transplant, and/or wherein one or more of hsa-miR-155, hsa-miR-628-5p, hsa-miR636 and hsa-miR-375 are decreased as compared levels from a subject requiring heart transplant.
1 more element
Dependencies are inferred from the claim text.