Cyclic peptoid oligomers, pharmaceutical compositions and methods of using the same

A peptoid oligomer according to formula I:

• or a pharmaceutically acceptable salt, solvate or prodrug thereof;
• and or a stereoisomer, isotopic variant or tautomer thereof;
• wherein
• each R1 is independently fluorenyl, 2-(indol-3-yl)ethyl, or a group selected from
• each R2 is independently substituted or unsubstituted alkyl, substituted or unsubstituted phenyl, haloalkyl, halo, substituted or unsubstituted alkoxy, or cyano;
• each R3 is independently H, methyl, or phenyl;
• each R4 is independently H, or methyl;
• each R5 is independently —NR6aR6b;
• each R6a and R6b is independently H, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl;
• the subscript n is 0 or 1;
• the subscript m is 0, 1, 2, 3, or 4;
• the subscript t is 1, 2, 3, 4, or 5;
• the subscript u is 0, 1, or 2;
• the subscript v is 0, 1, 2, 3, 4, or 5;
• and * denotes the attachment point;
• and
• provided that
• i) at least one of R1s is
• and at least one of R1s is fluorenyl, 2-(indol-3-yl)ethyl, or a group selected from
• and
• ii) the compound is other than
• wherein R is —(CH2)3NH2