Beta-turn peptidomimetic cyclic compounds for treating dry eye
AssigneeMimetogen Pharmaceuticals, Inc.
InventorsGarth CUMBERLIDGE, Karen MEEROVITCH, Teresa LAMA
Life of this patent
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Abstract
The present invention relates to methods of treating dry eye using β-turn peptidomimetic cyclic compounds or derivatives thereof. The β-turn peptidomimetic cyclic compounds can be used alone, in combination and/or in conjunction with one or more other compounds, molecules or drugs that treat dry eye.
Claims15
1-12. (canceled)
A method of treating dry eye in a subject in need thereof comprising administering to said subject an effective amount of β-turn peptidomimetic cyclic compound represented by structural Formula (I):
- wherein R1 and R3 are independently selected from hydrogen, C1 to C6 alkyl, aryl, or amino acid side chain substituent found in the twenty protein-amino acids;
- R2 and R4 are independently hydrogen or alkyl;
- or R1 and R2 together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group;
- or R3 and R4 together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group;
- R5 and R6 are hydrogen or C1 to C6 alkyl;
- Y is hydrogen or one or two aromatic substituents;
- X is selected from O, N, S, P, Se, C, alkylene of 1 to 6 carbon atoms, SO, SO2 or NH;
- n is 0, 1, 2, 3, 4 or 5;
- and LINKER selected from the group consisting of:
- NH2, OH, SH, COOH, CH3CO, CHO, and NH—CH2—COOH.
A method of treating dry eye in a subject in need thereof comprising administering to said subject an effective amount of a β-turn peptidomimetic cyclic compound represented by Formula 3Aa:
- or a pharmaceutically acceptable salt thereof.
A method of treating dry eye in a subject in need thereof comprising administering to said subject an effective amount of a β-turn peptidomimetic cyclic compound represented by Formula 3Ak:
- or a pharmaceutically acceptable salt thereof.
A method of stimulating mucin secretion in a subject in need thereof comprising administering to said subject an effective amount of β-turn peptidomimetic cyclic compound represented by structural Formula (I):
- wherein R1 and R3 are independently selected from hydrogen, C1 to C6 alkyl, aryl, or amino acid side chain substituent found in the twenty protein-amino acids;
- R2 and R4 are independently hydrogen or alkyl;
- or R1 and R2 together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group;
- or R3 and R4 together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group;
- R5 and R6 are hydrogen or C1 to C6 alkyl;
- Y is hydrogen or one or two aromatic substituents;
- X is selected from O, N, S, P, Se, C, alkylene of 1 to 6 carbon atoms, SO, SO2 or NH;
- n is 0, 1, 2, 3, 4 or 5;
- and LINKER selected from the group consisting of:
- NH2, OH, SH, COOH, CH3CO, CHO, and NH—CH2—COOH.
(canceled)
Dependencies are inferred from the claim text.