Methods and compounds for calcium ion channel regulation
AssigneeDuke University
InventorsGeoffrey S. Pitt, Adam S. Barnett, Xinhe Yin
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Abstract
The present invention generally relates to methods of modulating Cav1.2 channels and Cav1.2 channel activators.
Claims27
A method of increasing bone mass in a subject, comprising modulating Cav1.2 channel activity in bone of the subject, thereby increasing bone mass in the subject.
A method of preventing and/or treating osteoporosis and/or preventing the occurrence of compression fractures due to osteoporosis in a subject in need thereof, comprising modulating Cav1.2 channel activity in bone of the subject, thereby preventing and/or treating osteoporosis and/or preventing the occurrence of compression fractures due to osteoporosis in the subject.
A method of preventing or slowing bone mineral density loss in bone of a subject in need thereof, comprising modulating Cav1.2 channel activity in bone of the subject, thereby preventing or slowing bone mineral density loss in bone of the subject.
A compound comprising a Cav1.2 channel activator that increases a Cav1.2 channel activity.
Dependencies are inferred from the claim text.