Methods And Non-Immunogenic Compositions For Treating Inflammatory Disorders

An anti-inflammatory composition comprising a lyophilized activated plasma composition, wherein:

• (a) the plasma is obtained from a plurality of mammalian subjects;
• (b) the plasma is activated by contacting the plasma with a solid extraction material;
• and
• (c) the plasma is substantially free of white blood cells.

A method for making an anti-inflammatory cytokine composition, comprising:

• (a) obtaining a cytokine cell suspension from a mammalian donor;
• (b) contacting the suspension with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist;
• and
• (c) isolating the composition from the solid extraction material;
• (d) mixing the composition with a storage solution to make a storage stabilized composition;
• and
• (e) freezing the stabilized composition.