Method of generating an index score for mbl deficiency to predict cardiodiabetes risk

A method for predicting susceptibility or likelihood of a subject having a clinically-relevant mannose-binding lectin (MBL) deficiency to develop cardiodiabetes, comprising:

• a. obtaining measurement values of MBL mass and MBL activity level;
• b. obtaining measurement values for Fructosamine, C-peptide, and 1, 5 AG;
• c. calculating an MBL-inclusive index score based the measurements obtained in steps (a) and (b) using the following equation:
• LN
• 
• [
• MBL
• 
• 
• mass
• *
• 1
• ,
• 5
• 
• 
• AG
• 1.91
• MBL
• 
• 
• activity
• *
• Fructosamine
• 10.67
• *
• C
• 
• -
• 
• peptide
• 2.29
• ]
• ;
• d. comparing the MBL-inclusive index to reference values from a population;
• wherein an elevated MBL-inclusive index score correlates with a range in a higher unit of an ordered distribution of the population and indicates that the subject is less susceptible to or has a less likelihood of developing cardiovascular disease and/or cardiodiabetes, and wherein a low MBL-inclusive index score correlates with a range in a lower unit of an ordered distribution of the population and indicates that the subject is more susceptible to or has an increased likelihood of developing cardiovascular disease and/or cardiodiabetes.

A method for predicting susceptibility or likelihood of a subject having a clinically-relevant mannose-binding lectin (MBL) deficiency to develop cardiodiabetes, comprising:

• a. obtaining measurement values of MBL mass and MBL activity level;
• b. calculating an MBL-inclusive index score based the measurements obtained in step (a) using the following equation:
• i
• .
• 
• log
• 
• [
• MBL
• 
• 
• mass
• MBL
• 
• 
• activity
• ]
• ;
• c. comparing the MBL-inclusive index to reference values from a population;
• wherein an elevated MBL-inclusive index score correlates with a range in a higher unit of an ordered distribution of the population and indicates that the subject is less susceptible to or has a less likelihood of developing cardiovascular disease and/or cardiodiabetes, and wherein a low MBL-inclusive index score correlates with a range in a lower unit of an ordered distribution of the population and indicates that the subject is more susceptible to or has an increased likelihood of developing cardiovascular disease and/or cardiodiabetes.