Conjugate based systems for controlled drug delivery
AssigneeSmartCells, Inc.
InventorsTodd C. Zion, Thomas M. Lancaster
Life of this patent
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Abstract
Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation.
Claims39
A conjugate comprising a drug conjugated to one or more ligands wherein at least one ligand comprises a mannose, glucose, or L-fucose saccharide;
- wherein the conjugate is characterized in that, when the conjugate is administered to a mammal in the absence of an exogenous multivalent saccharide-binding molecule, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a saccharide.
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Dependencies are inferred from the claim text.