Inhibitors of hepatitis c virus

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• is T1, T2, T3, T4, T5, or T6;
• L is L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, L11 or L12;
• X is —O—, —CH2—, —OC(O)—, —C(O)O—,
• —C(O)—, —SO2—, —S(O)—, —N(R16)—, —S—, ═N—O— or a bond;
• M is a bond, C1-C6 alkylene, —O—, or —N(R16)—;
• Q is Q1, Q2, Q3, Q4, Q5, Q6 or Q7;
• E is E1, E2, E3, E4, E5, or E6;
• is aryl, heteroaryl or heterocyclic group wherein
• is optionally substituted with 1-4 W groups;
• J is —O—, —CH2—, —CF2—, —C(O)—, or —N(R16)—;
• G is —CO2H, —CONHSO2Z2, tetrazolyl, —CONHP(O)(R16)2, —P(O)(OH)(R16), or —P(O)(R16)2;
• T1 is C5-C12 spiro bicyclic carbocyclene that is attached to J and M through two adjacent carbons, wherein said spiro bicyclic carbocyclene is optionally substituted with 1-4 Z1 groups;
• T2 is C5-C12 fused bicyclic carbocyclene that is attached to J and M through two adjacent carbons, wherein said fused bicyclic carbocyclene is optionally substituted with 1-4 Z1 groups;
• T3 is C5-C12 bridged bicyclic carbocyclene that is attached to J and M through two adjacent carbons, wherein said bridged bicyclic carbocyclene is optionally substituted with 1-4 Z1 groups;
• T4 is C5-C12 spiro bicyclic heterocyclene that is attached to J and M through two adjacent atoms, wherein said spiro bicyclic heterocyclene is optionally substituted with 1-4 Z1 groups;
• T5 is C5-C12 fused bicyclic heterocyclene that is attached to J and M through two adjacent atoms, wherein said fused bicyclic heterocyclene is optionally substituted with 1-4 Z1 groups;
• T6 is C5-C12 bridged bicyclic heterocyclene that is attached to J and M through two adjacent atoms, wherein said bridged bicyclic heterocyclene is optionally substituted with 1-4 Z1 groups;
• L1 is C1-C8 alkylene or C2-C8 alkenylene;
• L2 is C1-C8 alkylene or C2-C8 alkenylene wherein said C1-C8 alkylene or said C2-C8 alkenylene is substituted with 1-4 halogen atoms;
• L3 is C1-C8 alkylene or C2-C8 alkenylene wherein said C1-C8 alkylene or said C2-C8 alkenylene is substituted with 1-4 Z3 groups and wherein said C1-C8 alkylene or C2-C8 alkenylene is optionally substituted with 1-4 halogen atoms;
• L4 is C1-C8 alkylene or C2-C8 alkenylene substituted with two geminal C1-C4 alkyl groups that come together to form a spiro C3-C8 cycloalkyl group, wherein L4 is optionally substituted with 1-4 Z1 groups;
• L5 is C1-C8 alkylene or C2-C8 alkenylene substituted with two geminal Z1 groups that come together to form a spiro 4-8 membered heterocyclyl group, wherein L5 is optionally substituted with 1-4 additional Z1 groups;
• L6 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene;
• L7 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene, wherein the carbon atoms of said heteroalkylene or heteroalkenylene is substituted with 1-4 halogen atoms;
• L8 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene, wherein said heteroalkylene or heteroalkenylene is substituted with 1-4 Z3 groups and said heteroalkylene or heteroalkenylene is optionally substituted with 1-4 halogen atoms;
• L9 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene substituted with two geminal C1-C4 alkyl groups that come together to form a spiro C3-C8 carbocyclyl group, wherein said L9 is optionally substituted with 1-4 Z1 groups;
• L10 is 2-8 membered heteroalkylene or 4-8 membered heteroalkenylene substituted with two geminal Z1 groups that come together to form a spiro 4-8 membered heterocyclyl group, wherein L10 is optionally substituted with 1-4 additional Z1 groups;
• L11 is L11A-L11B-L11C wherein L11A and L11C are each independently selected from C1-C6 alkylene, C1-C6 heteroalkylene, C2-C6 alkenylene or a bond and L11B is a 3- to 6-membered saturated or unsaturated ring containing 0 to 3 heteroatoms selected from N, O, or S, wherein L11A and L11C connect to L11B at two different ring atoms and L11 is optionally substituted with 1-4 Z1 groups;
• L12 is C3-C8 alkynylene that is optionally substituted with 1-4 Z1 groups;
• Q1 is H, C1-C8 alkyl, C3-C8 carbocyclyl, C6-C10 aryl, 5-6 membered heteroaryl, or 5-6 membered heterocyclyl, wherein when Q1 is not H, said Q1 is optionally substituted with 1-3 substituents independently selected from halogen, —OR6, —SR6, —N(R6)2, C6-C10 aryl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, —CN, —SO2(C1-6 alkyl), —S(O)(C1-C6 alkyl), —NR6SO2Z2, —SO2NR17R18, —NHCOOR16, —NHCOZ2, —NHCONHR16, —CO2R6, —C(O)R6, or —CON(R6)2;
• Q2 is C5-C10 spiro bicyclic carbocyclyl that is optionally substituted with 1-4 Z1 groups;
• Q3 is C5-C10 fused bicyclic carbocyclyl that is optionally substituted with 1-4 Z1 groups;
• Q4 is C5-C10 bridged bicyclic carbocyclyl that is optionally substituted with 1-4 Z1 groups;
• Q5 is 4-8 membered heterocyclyl having 1 heteroatom selected from N, O or S wherein Q5 is optionally substituted with 1-4 Z1 groups;
• Q6 is C1-C8 alkyl, C3-C8 carbocyclyl, C6-C10 aryl, 5-6 membered heteroaryl, or 5-6 membered heterocyclyl, wherein Q6 is substituted with 1 oxo group and optionally substituted with 1 to 3 substituents independently selected from halogen, —OR6, —SR6, —N(R6)2, C6-C10 aryl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, —NO2, —CN, —CF3, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —NR6SO2Z2, —SO2NR17R18, —NHCOOR16, —NHCOZ2, —NHCONHR16, —CO2R6, —C(O)R6, and —CON(R6)2;
• Q7 is selected from C3-C8 carbocyclyl, wherein Q7 is substituted with 4-8 F atoms and each carbon of Q7 is substituted with 0-2 F atoms;
• E1 is C2-C6 alkenyl;
• E2 is C1-C6 alkyl;
• E3 is C1-C6 haloalkyl;
• E4 is C2-C6 haloalkenyl;
• E5 is C3-C6 carbocyclyl;
• E6 is C1-C6 alkyl substituted with —OCH3, —OCD3, —OCF3, or —OCF2H;
• W is independently W1, W2, W3, W4, W5, W6 or W7;
• W1 is oxo, halogen, —OR6, C1-C6 alkyl, —CN, —CF3, —SR6, —C(O)2R6, —C(O)N(R6)2, —C(O)R6, —N(R6)C(O)R6, —SO2(C1-C6 alkyl), —S(O)(C1-C6 alkyl), C3-C8 carbocyclyl, C3-C8 cycloalkoxy, C1-C6 haloalkyl, —N(R6)2, —NR6(C1-C6 alkyl)O(C1-C6 alkyl), halo(C1-C6 alkoxy), —NR6SO2R6, —SO2N(R6)2, —NHCOOR6, —NHCONHR6, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl or —O(4-10 membered heterocyclyl), wherein said C1-C6 alkyl, C3-C8 carbocyclyl, C3-C8 cycloalkoxy, C1-C6 haloalkyl, halo(C1-C6 alkoxy), C6-C10 aryl, 5-14 membered heteroaryl, or 4-10 membered heterocyclyl is optionally substituted with 1-4 Z1c groups;
• W2 is C1-C6 alkoxy substituted with a 5-14 membered heteroaryl or C6-C10 aryl;
• wherein said heteroaryl or aryl is substituted with 1-4 Z1c groups;
• W3 is C2-C6 alkynyl substituted with an C6-C10 aryl, C3-C8 carbocyclyl, C1-C8 alkyl, C1-C6 haloalkyl, 4-10 membered heterocyclyl, or 5-14 membered heteroaryl;
• wherein said aryl, carbocyclyl, alkyl, haloalkyl, heterocyclyl, or heteroaryl is optionally substituted with 1-4 Z1 groups;
• W4 is —SF5;
• W5 is —O(C2-C6 alkyl)OR22 wherein R22 is an C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl that is optionally substituted with 1-4 Z1 groups;
• W6 is —O(C2-C6 alkyl)NR16R22 wherein R22 is an C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl that is optionally substituted with 1-4 Z1 groups;
• W7 is —O(5-14 membered heteroaryl);
• wherein said —O(5-14 membered heteroaryl) is optionally substituted with 1-4 Z1 groups and 2 adjacent substituents of said —O(5-14 membered heteroaryl) may be taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms independently selected from N, O, or S;
• R6 is H, C1-C6 alkyl or C6-C10 aryl, wherein said C6-C10 aryl or C1-C6 alkyl is optionally substituted with 1 to 4 substituents independently selected from halogen, C1-C6 alkyl, C6-C10 aryl, C3-C8 carbocyclyl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, halo(C1-C6 alkoxy), —OH, —O(C1-C6 alkyl), —SH, —S(C1-C6 alkyl), —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —C(O)(C1-C6 alkyl), —SO2N(C1-C6 alkyl)2, —NHCOO(C1-C6 alkyl), —NHCO(C1-C6 alkyl), —NHCONH(C1-C6 alkyl), —CO2(C1-C6 alkyl), and —C(O)N(C1-C6 alkyl)2;
• R16 is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, wherein said C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl of R16 is optionally substituted with 1-4 Z1c groups;
• R17 and R18 are each independently selected from H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, —C(O)R16, —C(O)OR16, C6-C10 aryl, 5-14 membered heteroaryl or 4-10 membered heterocyclyl, wherein said alkyl, alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl of R17 or R18 is optionally substituted with 1-4 Z1a groups, or R17 and R18 together with the nitrogen to which they are attached form a 4-7 membered heterocyclyl group, wherein said 4-7 membered heterocyclyl group is optionally substituted with 1-4 Z1c groups;
• each Z1 is independently oxo, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)R16, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)R1, —NR16C(O)NR17R18, —NR16S(O)2R16, —NR16S(O)2NR17R18, —NR16S(O)2OR16, —OR16, —OC(O)R16, —OC(O)NR17R18, —SR16, —S(O)R16, —S(O)2R16 or —S(O)2NR17R18 wherein said alkyl, alkenyl, alkynyl, carbocyclyl, bicyclic carbocyclyl, aryl, heteroaryl or heterocyclyl of Z1 is optionally substituted with 1-4 Z1a groups;
• each Z1a is independently oxo, halogen, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)R16, —C(O)OR16, —C(O)NR17R18, —NR17—NR18, —NR16C(O)R16, —NR16C(I)OR16, —NR16C(O)NR17R18, —NR16S(O)2R16, —NR16S(O)2NR17R18, —NR16S(O)2OR16, —OR16, —OC(O) R16, —OC(O)NR17R18, —SR16, —S(O)R16, —S(O)2R16 or —S(O)2NR17R18 wherein said alkenyl, alkynyl, carbocyclyl, bicyclic carbocyclyl, aryl, heteroaryl or heterocyclyl of Z1a is optionally substituted with 1-4 Z1c groups;
• each Z1c is independently oxo, halogen, C1-C8 alkyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)(C1-C8 alkyl), —C(O)O(C1-C8 alkyl), —C(O)N(C1-C8 alkyl)2, —NH2, —NH(C1-C8 alkyl), —N(C1-C8 alkyl)2, —NHC(O)O(C1-C8 alkyl), —NHC(O)(C1-C8 alkyl), —NHC(O)NH(C1-C8 alkyl), —OH, —O(C1-C8 alkyl), C3-C8 cycloalkoxy, C5-C10 bicyclic carbocyclyloxy, —S(C1-C8 alkyl) or —S(O)2N(C1-C8 alkyl)2 wherein said alkyl, carbocyclyl, bicyclic carbocyclyl, aryl, heteroaryl, heterocyclyl or cycloalkoxy portion of Z1c is optionally substituted with 1-4 halogen atoms or C1-C6 alkoxy groups;
• each Z2 is independently C1-C8 alkyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —NR17R18 or —OR16 wherein any alkyl, carbocyclyl, bicyclic carbocyclyl, aryl, heteroaryl or heterocyclyl portion of Z2 is optionally substituted with 1-4 Z2a groups;
• each Z2a is independently hydrogen, oxo, halogen, C1-C8 alkyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —(C2-C8 alkynyl)aryl, —(C2-C8 alkynyl)heteroaryl, —CN, —C(O)(C1-C6 alkyl), —C(O)O(C1-C6 alkyl), —C(O)N(C1-C6 alkyl)2, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —NHC(O)O(C1-C6 alkyl), —NHC(O)(C1-C6 alkyl), —NHC(O)NH(C1-C6 alkyl), —OH, —O(C1-C6 alkyl), halo(C1-C6 alkoxy), C3-C8 cycloalkoxy, —S(C1-C6 alkyl), or —SO2N(C1-C6 alkyl)2;
• wherein any alkyl, alkynyl, carbocyclyl, cycloalkoxy, bicyclic carbocyclyl, aryl, heteroaryl or heterocyclyl portions of Z2a is optionally substituted with 1-4 halogen or C1-C6 alkoxy groups;
• each Z3 is independently oxo, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 carbocyclyl, C5-C10 bicyclic carbocyclyl, C1-C8 haloalkyl, C6-C10 aryl, 5-14 membered heteroaryl, 4-10 membered heterocyclyl, —CN, —C(O)OR16, —C(O)NR17R18, —NR17R18, —NR16C(O)NR17R18, —OR16, —SR16 or —SO2R16, wherein any alkenyl, alkynyl, carbocyclyl, aryl, heteroaryl or heterocyclyl portion of Z3 is optionally substituted with 1-4 halogen.