Mosquitocidal xenorhabdus, lipopeptide and methods
AssigneeWisconsin Alumi Research Foundation
InventorsJerald Coleman ENSIGN, Que LAN, David DYER
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Abstract
Provided is a bacterial strain which produces a family of mosquitocidal toxins, Xenorhabdus MT, on deposit with the American Type Culture Collection, PTA-6826, insecticidal compositions comprising the mosquitocidal toxin(s) produced by Xenorhabdus MT, a mosquitocidal toxin preparation prepared from spent culture medium, whole culture or cells or a mixture thereof, of Xenorhabdus MT and method of insect control, especially mosquito control. Also provided are microbial compounds (same as mosquitocidal toxins) compositions comprising them and use in formulating therapeutic and other antimicrobial compositions, and methods of use for inhibiting microbial growth and for treating infection.
Claims20
A method of controlling an insect comprising the step of applying to an environment of the insect an effective amount of a lipopeptide toxin having functional activity against an insect, wherein said lipopeptide toxin is produced by a pure bacterial culture of Xenorhabdus MT deposited with the ATCC as PTA-6826.
A method of controlling a microorganism, said method comprising the step of administering an effective amount of a mosquitocidal and/or antimicrobial composition comprising a lipopeptide toxin produced by the Xenorhabdus MT deposited with the American Type Culture Collection as PTA-6826, said toxin comprising histidine, diaminobutyric acid, asparagine and/or aspartate, serine and glycine, and at least one saturated straight chain fatty acid, a 2-oxo fatty acid, 3-oxo fatty acid or a 4-oxo fatty acid, wherein the fatty acid has a chain length of from C8 to C20 or of from C10 to C18.
A method for treating an infection caused by a microorganism in a subject, said method comprises the step of administering, to a subject in need of treatment therefor, a therapeutically effective amount of a mosquitocidal and/or antimicrobial composition comprising a lipopeptide toxin produced by the Xenorhabdus MT deposited with the American Type Culture Collection as PTA-6826, said toxin comprising histidine, diaminobutyric acid, asparagine and/or aspartate, serine and glycine, and at least one saturated straight chain fatty acid, a 2-oxo fatty acid, 3-oxo fatty acid or a 4-oxo fatty acid, wherein the fatty acid has a chain length of from C8 to C20 or of from C10 to C18.
Dependencies are inferred from the claim text.