Transcription factor decoys for the treatment and prevention of infections caused by bacteria including clostridium difficile
AssigneeProcarta Biosystems Ltd.
InventorMichael MCARTHUR
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Abstract
Decoy nucleic acid sequences comprising a binding site for a target transcription factor, wherein the binding site is not operably linked to a gene, and wherein the transcription factor comprises a regulator of expression of a gene or genes in Clostridium difficile encoding one or more of: (i) a cellular growth factor; (ii) a cellular toxin; (iii) a cellular sporulation factor; (iv) a cellular stress response; and/or (v) a cellular essential gene are described. Uses of the decoys in antibacterial complexes for the treatment of bacterial infections are also described.
Claims26
A decoy nucleic acid sequence comprising a binding site for a target transcription factor, wherein the binding site is not operably linked to a gene, and wherein the transcription factor comprises a regulator of expression of a gene or genes in Clostridium difficile encoding one or more of:
- (i) a cellular growth factor;
- (ii) a cellular toxin;
- (iii) a cellular sporulation factor;
- (iv) a cellular stress response;
- or
- (v) a cellular essential gene.
An antibacterial complex comprising one or more decoy nucleic acid sequences and one or more delivery moieties, wherein the decoy nucleic acid sequences comprise a binding site for a target transcription factor, wherein the binding site is not operably linked to a gene, and wherein the transcription factor comprises a regulator of expression of a gene or genes in Clostridium difficile encoding one or more of:
- (i) a cellular growth factor;
- (ii) a cellular toxin;
- (iii) a cellular sporulation factor;
- (iv) a cellular stress response;
- or
- (v) a cellular essential gene.
The use of a decoy nucleic acid sequence for the treatment of Clostridium difficile infection, wherein the decoy nucleic acid sequence comprises a binding site for a target transcription factor, wherein the binding site is not operably linked to a gene, and wherein the transcription factor comprises a regulator of expression of a gene or genes in Clostridium difficile encoding one or more of:
- (i) a cellular growth factor;
- (ii) a cellular toxin;
- (iii) a cellular sporulation factor;
- (iv) a cellular stress response;
- or
- (v) a cellular essential gene.
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Dependencies are inferred from the claim text.