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AssigneesUniversity of North Texas Health Science Center, Texas Christian University
InventorsZygmunt Gryczynski, Ignacy Gryczynski, Rafal Fudala, Badri P. Maliwal
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The present invention includes compositions and methods for fluorescence-based multiplex probe to simultaneously detect one or more enzymatic activities comprising: a first enzymatic target having a first end and a second end, wherein the first end of the first enzymatic target is attached to a central body and the second end of the first enzymatic target is attached to a first fluorophore; a second enzymatic target having a first end and a second end, wherein the first end of the second enzymatic target is attached to the central body and the second end of the second enzymatic target is attached to a third fluorophore; wherein the central body comprises at least one second fluorophore; wherein the first enzymatic target comprises a specific cleavage site of a first enzyme that cleaves the first enzymatic target; and wherein the second enzymatic target comprises a specific cleavage site of a second enzyme.
A fluorescence-based multiplex probe to simultaneously detect one or more enzymatic activities comprising:
A fluorescence-based multiplex probe to simultaneously detect two or more proteinase activities comprising:
A method of simultaneously detecting proteinase activity of at least two proteinases in a sample comprising:
A method of diagnosing a patient suspected of being afflicted with a disease comprising:
Dependencies are inferred from the claim text.