Complex sets of mirnas as non-invasive biomarkers for psoriasis
OwnerAndreas Keller, Markus Beier +3inventors
InventorsAndreas Keller, Markus Beier, Eckart Meese, Petra Leidinger, Valesca Boisguerin
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Abstract
The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject.
Claims12
A method for diagnosing and/or prognosing of psoriasis comprising the steps of:
- (i) determining an expression profile of a set comprising at least two miRNAs representative thr psoriasis in a blood sample from a subject, and
- (ii) comparing said expression profile to a reference, wherein the comparison of said expression profile to said reference allows for the diagnosis and/or prognosis of psoriasis,
- wherein the nucleotide sequences of the miRNAs comprised in the set are selected from the group consisting of SEQ ID NO 1 to 283, a fragment thereof, and a sequence having at least 80% sequence identity thereto.
-13. (canceled)
A kit for diagnosing and/or prognosing of psoriasis comprising
- (i) means for determining an expression profile of a set comprising at least two miRNAs representative for psoriasis in a blood sample from a subject, and
- (ii) at least one reference.
- wherein the nucleotide sequences of said miRNAs are selected from the group consisting of SEQ ID NO:
- 1 to 283, a fragment thereof, and a sequence having at least 80% sequence identity thereto.
-21. (canceled)
Dependencies are inferred from the claim text.