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US 2014/0274780 A1Published application
Methods of improving survival in cancer
OwnerGregory Milesinventor
Life of this patent
Estimating the term…
Abstract
Methods of improving cancer therapy outcomes are provided. Diagnostics useful for evaluating patients based on microRNA signatures of cancer tissue are provided.
Claims6
A method of classifying human patients diagnosed with Ovarian cancer, comprising,
- obtaining samples of ovarian cancer cells from the patients,
- determining the expression levels of microRNA Classes selected from the group comprising Ov1A, Ov1B, Ov2A, Ov2B, Ov3 microRNAs in each sample,
- determining whether the expression levels of each of said microRNAs are above or below the benchmark for each microRNA,
- calculating a PScore for each patient, and
- classifying patients having PScore of greater than or equal to 0.5 for a Class of microRNA as patients with tumors exhibiting the signature of that Class.
2 more elements
A method of classifying human patients diagnosed with Glioblastoma multiforme, comprising,
- obtaining samples of ovarian cancer cells from the patients,
- determining the expression levels of microRNA Classes selected from the group comprising G1A, G2A and G2B microRNAs in each sample,
- determining whether the expression levels of each of said microRNAs are above or below the benchmark for each microRNA,
- calculating a PScore for each patient, and
- classifying patients having PScore of greater than or equal to 0.5 for a Class of microRNA as patients with tumors exhibiting the signature of that Class.
2 more elements
A kit for measuring the level of expression of the microRNAs selected from the group of OV1A, OV1B, OV2A, OV2B, Ov3, G1A, G2A and G2B microRNAs.
Dependencies are inferred from the claim text.