Methods and compositions for treatment of breast cancer
AssigneeCity of Hope
InventorsShizhen Emily Wang, Xiwei WU, Miranda Y. Fong
Life of this patent
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Abstract
Provided are methods of treating breast cancer in a subject in need thereof comprising administering to the subject an effective amount of an inhibitor of miR-105 or an inhibitor of miR-122 are provided. Also provided herein are methods of determining a level of miR-105 or a level of miR-122 in a subject that has or is at risk for developing breast cancer. The method includes obtaining a biological sample from the subject and determining a level of miR-105 or a level of miR-122 or a combination thereof in the biological sample, wherein a higher level of miR-105 or miR-122 as compared to a control indicates that the subject has or is at risk of developing breast cancer.
Claims22
A method of determining a level of miR-105 or a level of miR-122 or a combination thereof in a subject that has or is at risk for developing breast cancer, the method comprising the steps of:
- (a) obtaining a biological sample from the subject;
- and
- (b) determining a level of miR-105 or a level of miR-122 or a combination thereof in the biological sample.
A kit comprising
- (a) a binding agent capable of binding to a substance within a biological sample from a subject that has or is at risk for developing breast cancer, wherein said substance is:
- (i) a nucleic acid sequence comprising a miR-105 or miR-122 sequence;
- or
- (ii) a nucleic acid amplification product of miR-105 or miR-122;
- and
- (b) a detecting reagent or a detecting apparatus capable of detecting binding of said binding agent to said substance.
An in vitro complex comprising a nucleic acid probe hybridized to a nucleic acid, wherein said nucleic acid is a miR-105 or miR-122 sequence extracted from a subject that has or is at risk for developing breast cancer or is an amplification product of a miR-105 or miR-122 sequence extracted from a subject that has or is at risk for developing breast cancer.
Dependencies are inferred from the claim text.