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US 2014/0274759 A1Published application
Modification of polypeptides
AssigneeBicycle Therapeutics Limited
InventorsEdward WALKER, Catherine STACE
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Abstract
The invention provides a method for conjugating a peptide displayed on a genetic display system to a molecular scaffold performed on an ion exchange resin.
Claims12
A method for conjugating a peptide displayed on a genetic display system to a molecular scaffold, comprising the steps of:
- (a) combining polypeptides displayed on a genetic display system with a purification resin such that the display system is bound to the resin and treating the bound display system with a reducing agent;
- (b) exposing the bound display system to the molecular scaffold;
- (c) removing unreacted molecular scaffold from the bound display system;
- and
- (d) eluting the display system from the purification resin.
2 more elements
Dependencies are inferred from the claim text.