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AssigneeReference Biolabs Inc.
InventorsYoung Kee SHIN, Young-Deug KIM, Jun Young CHOI, Myung Seok LEE
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A multi-transmembrane protein antigen includes a polypeptide corresponding to an extracellular loop of the multi-transmembrane protein, the N-terminal and C-terminal of the polypeptide being fixed on a solid substrate or the N-terminal and C-terminal being attached to both ends of a linker to form a cyclic structure, an antibody specifically binding to the antigen or an antigen-binding fragment thereof, and a method for screening an antibody specifically binding to the antigen. The present invention may be usefully employed for effective production of antibodies for multi-transmembrane proteins that play important roles in disease-related phenomena such as cell signaling.
A multi-transmembrane protein antigen comprising a polypeptide corresponding to an extracellular loop of a multi-transmembrane protein, wherein an N-terminal and a C-terminal of the polypeptide are fixed on a solid substrate, or an N-terminal and a C-terminal of the polypeptide are attached to both ends of a linker to form a cyclic structure.
An antibody or a fragment of the antibody specifically binding to a multi-transmembrane protein antigen, wherein the multi-transmembrane protein antigen comprises a polypeptide corresponding to an extracellular loop of a multi-transmembrane protein, and an N-terminal and a C-terminal of the polypeptide are fixed on a solid substrate or an N-terminal and a C-terminal of the polypeptide are attached to both ends of a linker to form a cyclic structure.
Dependencies are inferred from the claim text.